Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type
The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America....
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/627401 |
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| _version_ | 1849467525277941760 |
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| author | Harinder Gill Raymond H. S. Liang Eric Tse |
| author_facet | Harinder Gill Raymond H. S. Liang Eric Tse |
| author_sort | Harinder Gill |
| collection | DOAJ |
| description | The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America. Histopathological and immunophenotypical hallmarks include angiocentricity, angiodestruction, expression of cytoplasmic CD3 epsilon (ε), CD56, and cytotoxic molecules and evidence of Epstein-Barr virus (EBV) infection. Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy. On the other hand, multiagent chemotherapy is the mainstay of treatment for advanced or disseminated disease. L-asparaginase-containing regimens have shown promise in treating this condition. The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined. Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease. |
| format | Article |
| id | doaj-art-e6f0dc86fcd247b49b6c78167a5afbcf |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-e6f0dc86fcd247b49b6c78167a5afbcf2025-08-20T03:26:10ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/627401627401Extranodal Natural-Killer/T-Cell Lymphoma, Nasal TypeHarinder Gill0Raymond H. S. Liang1Eric Tse2Division of Haematology, Medical Oncology and Bone Marrow Transplantation, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong KongDivision of Haematology, Medical Oncology and Bone Marrow Transplantation, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong KongDivision of Haematology, Medical Oncology and Bone Marrow Transplantation, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong KongThe World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Extranodal nasal NK/T-cell lymphoma is more frequent in the Far East and Latin America. Histopathological and immunophenotypical hallmarks include angiocentricity, angiodestruction, expression of cytoplasmic CD3 epsilon (ε), CD56, and cytotoxic molecules and evidence of Epstein-Barr virus (EBV) infection. Early stage disease, in particular for localized lesion in the nasal region, is treated with chemotherapy and involved-field radiotherapy. On the other hand, multiagent chemotherapy is the mainstay of treatment for advanced or disseminated disease. L-asparaginase-containing regimens have shown promise in treating this condition. The role of autologous hematopoietic stem cell transplantation is yet to be clearly defined. Allogeneic hematopoietic stem cell transplantation, with the putative graft-versus-lymphoma effect, offers a potentially curative option in patients with advanced disease.http://dx.doi.org/10.1155/2010/627401 |
| spellingShingle | Harinder Gill Raymond H. S. Liang Eric Tse Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type Advances in Hematology |
| title | Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type |
| title_full | Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type |
| title_fullStr | Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type |
| title_full_unstemmed | Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type |
| title_short | Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type |
| title_sort | extranodal natural killer t cell lymphoma nasal type |
| url | http://dx.doi.org/10.1155/2010/627401 |
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