Enhancing Antioxidant and Cytotoxic Properties of CeO<sub>2</sub> Through Silver Decoration: A Study on Ag@CeO<sub>2</sub> Nanocomposites
In this study, silver-decorated cerium oxide (Ag@CeO<sub>2</sub>) nanoparticles were synthesized through a simple mixing and pyrolysis process to enhance their antioxidant and antitumor properties. The synthesis methods for Ag@CeO<sub>2</sub> were optimized, resulting in nano...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/15/10/748 |
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| Summary: | In this study, silver-decorated cerium oxide (Ag@CeO<sub>2</sub>) nanoparticles were synthesized through a simple mixing and pyrolysis process to enhance their antioxidant and antitumor properties. The synthesis methods for Ag@CeO<sub>2</sub> were optimized, resulting in nanoparticles with varying antioxidant activities. Notably, the embedding of Ag nanoparticles within CeO<sub>2</sub> during pyrolysis significantly improved the antioxidant activity and stability of the nanoparticles, leading to enhanced antitumor effects. The Ag@CeO<sub>2</sub> nanoparticles exhibited strong cytotoxicity against tumor cells (MCF-7) while maintaining low toxicity toward normal cells (HUVECs). These properties, combined with their ability to modulate mitochondrial membrane potential, position Ag@CeO<sub>2</sub> as a promising candidate for electrochemical therapy (ECT). This study highlights the antioxidant potential and the potential of Ag@CeO<sub>2</sub> nanoparticles in tumor treatment and provides new insights into the application of nanomaterials in ECT. |
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| ISSN: | 2079-4991 |