CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling

CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling

Abstract B cells play a critical role in the pathogenesis of autoimmune inflammatory diseases such as multiple sclerosis (MS). As a receptor of prostaglandin D2, chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) is known to be involved in Th2 cell activation, but its functi...

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Bibliographic Details
Main Authors: Jiao Liu, Bei Wang, Chunyan Wu, Ting Wang, Jie Zhou, Yujun Shen, Ying Yu, Shengkai Zuo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neuroinflammation
Subjects:
CRTH2
B cells
IL-1β
Experimental autoimmune encephalomyelitis
p38 MAPK signaling
Online Access:https://doi.org/10.1186/s12974-025-03513-4
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