Small vessel occlusion and syphilis in patients with first-ever ischemic stroke
ABSTRACT Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2021-03-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000200103&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849471057883299840 |
|---|---|
| author | Matheus Gomes Ferreira Valeria Cristina Scavasine Giovanni Luís Breda Bernardo Montesanti Machado de Almeida Viviane de Hiroki Flumignan Zétola Marcos Christiano Lange |
| author_facet | Matheus Gomes Ferreira Valeria Cristina Scavasine Giovanni Luís Breda Bernardo Montesanti Machado de Almeida Viviane de Hiroki Flumignan Zétola Marcos Christiano Lange |
| author_sort | Matheus Gomes Ferreira |
| collection | DOAJ |
| description | ABSTRACT Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). Methods: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients were classified according to the ASCOD phenotyping as SVD — when SVD was the potential causal mechanism (S1) — or non-SVD — when SVD was uncertain (S2), unlike (S3), or not detected (S0). Results: Syphilis was positive in 32 (12%) patients. When comparing patients with positive and negative serology, the only significant difference was SVD as the causal mechanism (S1) in patients with positive results: 9 (28%) vs. 22 (9%), p<0.01. Conclusion: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis. |
| format | Article |
| id | doaj-art-e6d7ae68b4b049ad823c72495ce3db82 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e6d7ae68b4b049ad823c72495ce3db822025-08-20T03:24:58ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272021-03-0179210310610.1590/0004-282x-anp-2020-0178Small vessel occlusion and syphilis in patients with first-ever ischemic strokeMatheus Gomes Ferreirahttps://orcid.org/0000-0002-5288-4739Valeria Cristina Scavasinehttps://orcid.org/0000-0002-2972-0971Giovanni Luís Bredahttps://orcid.org/0000-0001-7092-8830Bernardo Montesanti Machado de Almeidahttps://orcid.org/0000-0001-5293-3652Viviane de Hiroki Flumignan Zétolahttps://orcid.org/0000-0001-8464-9488Marcos Christiano Langehttps://orcid.org/0000-0002-0405-7157ABSTRACT Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). Methods: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients were classified according to the ASCOD phenotyping as SVD — when SVD was the potential causal mechanism (S1) — or non-SVD — when SVD was uncertain (S2), unlike (S3), or not detected (S0). Results: Syphilis was positive in 32 (12%) patients. When comparing patients with positive and negative serology, the only significant difference was SVD as the causal mechanism (S1) in patients with positive results: 9 (28%) vs. 22 (9%), p<0.01. Conclusion: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000200103&tlng=enSyphilisStrokeCerebral Small Vessel Diseases |
| spellingShingle | Matheus Gomes Ferreira Valeria Cristina Scavasine Giovanni Luís Breda Bernardo Montesanti Machado de Almeida Viviane de Hiroki Flumignan Zétola Marcos Christiano Lange Small vessel occlusion and syphilis in patients with first-ever ischemic stroke Arquivos de Neuro-Psiquiatria Syphilis Stroke Cerebral Small Vessel Diseases |
| title | Small vessel occlusion and syphilis in patients with first-ever ischemic stroke |
| title_full | Small vessel occlusion and syphilis in patients with first-ever ischemic stroke |
| title_fullStr | Small vessel occlusion and syphilis in patients with first-ever ischemic stroke |
| title_full_unstemmed | Small vessel occlusion and syphilis in patients with first-ever ischemic stroke |
| title_short | Small vessel occlusion and syphilis in patients with first-ever ischemic stroke |
| title_sort | small vessel occlusion and syphilis in patients with first ever ischemic stroke |
| topic | Syphilis Stroke Cerebral Small Vessel Diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000200103&tlng=en |
| work_keys_str_mv | AT matheusgomesferreira smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke AT valeriacristinascavasine smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke AT giovanniluisbreda smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke AT bernardomontesantimachadodealmeida smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke AT vivianedehirokiflumignanzetola smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke AT marcoschristianolange smallvesselocclusionandsyphilisinpatientswithfirsteverischemicstroke |