Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study
Introduction. Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long durat...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/3920298 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850167671777132544 |
|---|---|
| author | Prachaya Srivanitchapoom Jung E. Park Nivethida Thirugnanasambandam Pattamon Panyakaew Vesper Fe Marie Ramos Sanjay Pandey Tianxia Wu Mark Hallett |
| author_facet | Prachaya Srivanitchapoom Jung E. Park Nivethida Thirugnanasambandam Pattamon Panyakaew Vesper Fe Marie Ramos Sanjay Pandey Tianxia Wu Mark Hallett |
| author_sort | Prachaya Srivanitchapoom |
| collection | DOAJ |
| description | Introduction. Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long duration trains of PAS. In the present study, we explored an LTD-like effect using very short duration and low frequency of PAS10 ms protocols in human M1. Methods. Six protocols of low frequency PAS10 ms (ranging from 0.2 Hz to 1 Hz) were investigated with very short durations of 1 and 2 minutes stimulation. Six healthy volunteers were included in each protocol. We obtained motor-evoked potentials from right abductor pollicis brevis muscle before and after applying PAS10 ms up to 30 minutes. After we found PAS10 ms protocol which induced an LTD-like effect, we tested that protocol on additional 5 subjects. Results. One-way repeated-measures ANOVA showed that only the group of 1-minute stimulation of 0.25 Hz induced an LTD-like effect. When adding the additional subjects, the effect remained and lasted for 30 minutes. Conclusion. Low frequency and very short duration of PAS10 ms potentially induced an LTD-like effect in human M1. With further verification, this method might be useful for research relating to synaptic plasticity by reducing the duration of study and minimizing subject discomfort. |
| format | Article |
| id | doaj-art-e6d61c2e4bab430ca964a9cd0bac0de2 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e6d61c2e4bab430ca964a9cd0bac0de22025-08-20T02:21:10ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/39202983920298Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory StudyPrachaya Srivanitchapoom0Jung E. Park1Nivethida Thirugnanasambandam2Pattamon Panyakaew3Vesper Fe Marie Ramos4Sanjay Pandey5Tianxia Wu6Mark Hallett7Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAGovind Ballabh Pant Hospital, New Delhi 110002, IndiaClinical Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USAIntroduction. Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long duration trains of PAS. In the present study, we explored an LTD-like effect using very short duration and low frequency of PAS10 ms protocols in human M1. Methods. Six protocols of low frequency PAS10 ms (ranging from 0.2 Hz to 1 Hz) were investigated with very short durations of 1 and 2 minutes stimulation. Six healthy volunteers were included in each protocol. We obtained motor-evoked potentials from right abductor pollicis brevis muscle before and after applying PAS10 ms up to 30 minutes. After we found PAS10 ms protocol which induced an LTD-like effect, we tested that protocol on additional 5 subjects. Results. One-way repeated-measures ANOVA showed that only the group of 1-minute stimulation of 0.25 Hz induced an LTD-like effect. When adding the additional subjects, the effect remained and lasted for 30 minutes. Conclusion. Low frequency and very short duration of PAS10 ms potentially induced an LTD-like effect in human M1. With further verification, this method might be useful for research relating to synaptic plasticity by reducing the duration of study and minimizing subject discomfort.http://dx.doi.org/10.1155/2016/3920298 |
| spellingShingle | Prachaya Srivanitchapoom Jung E. Park Nivethida Thirugnanasambandam Pattamon Panyakaew Vesper Fe Marie Ramos Sanjay Pandey Tianxia Wu Mark Hallett Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study Neural Plasticity |
| title | Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study |
| title_full | Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study |
| title_fullStr | Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study |
| title_full_unstemmed | Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study |
| title_short | Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study |
| title_sort | inducing ltd like effect in the human motor cortex with low frequency and very short duration paired associative stimulation an exploratory study |
| url | http://dx.doi.org/10.1155/2016/3920298 |
| work_keys_str_mv | AT prachayasrivanitchapoom inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT jungepark inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT nivethidathirugnanasambandam inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT pattamonpanyakaew inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT vesperfemarieramos inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT sanjaypandey inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT tianxiawu inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy AT markhallett inducingltdlikeeffectinthehumanmotorcortexwithlowfrequencyandveryshortdurationpairedassociativestimulationanexploratorystudy |