Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection
Food contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to the neurotoxicity of these toxins. Based on the latest literature data, we presented the association of common <i>Fusarium</i> mycotoxins with neurolo...
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MDPI AG
2025-01-01
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| Series: | Toxins |
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| author | Aleksandra Kuć-Szymanek Daria Kubik-Machura Klaudia Kościelecka Tomasz Męcik-Kronenberg Lidia Radko |
| author_facet | Aleksandra Kuć-Szymanek Daria Kubik-Machura Klaudia Kościelecka Tomasz Męcik-Kronenberg Lidia Radko |
| author_sort | Aleksandra Kuć-Szymanek |
| collection | DOAJ |
| description | Food contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to the neurotoxicity of these toxins. Based on the latest literature data, we presented the association of common <i>Fusarium</i> mycotoxins with neurological diseases. Articles from 2001 to 2024 were analyzed. The mechanisms underlying the neurotoxicity of the described mycotoxins were presented. They are mainly related to the increase in oxidative stress in neuronal cells, which leads to higher levels of pro-inflammatory cytokines as IL-1β, IL-6 and TNF-α, enzymatic activity as GST, GPx, CAT and SOD and neurotransmitter dysfunction (5-HT, serotonin, dopamine and GABA). At the end of the article, based on the literature data, we attempted to present ways to mitigate mycotoxin neurotoxicity using mainly natural substances of plant origin. The data in this review focus on the <i>Fusarium</i> mycotoxins most frequently found in food and will be useful as comparative information for future studies. It is important to conduct further studies to mitigate the neurotoxic effects of <i>Fusarium</i> mycotoxins in order to reduce the development of diseases of the nervous system. |
| format | Article |
| id | doaj-art-e6d242d787f14d73ae10b10b7875bbbd |
| institution | Kabale University |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Toxins |
| spelling | doaj-art-e6d242d787f14d73ae10b10b7875bbbd2025-01-24T13:51:14ZengMDPI AGToxins2072-66512025-01-011712410.3390/toxins17010024Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of NeuroprotectionAleksandra Kuć-Szymanek0Daria Kubik-Machura1Klaudia Kościelecka2Tomasz Męcik-Kronenberg3Lidia Radko4Faculty of Medical and Health Sciences, University in Siedlce, Stanisława Konarskiego St. 2, 08-110 Siedlce, PolandProvincial Specialist Hospital No. 5 St. Barbara in Sosnowiec, Trauma Center, Plac Medyków St. 1, 41-200 Sosnowiec, PolandMunicipal Hospital in Zabrze, Zamkowa St. 4, 41-803 Zabrze, PolandDepartment of Pathomorphology, Faculty of Medical Sciences in Zabrze, 3 Maja St. 13, 41-800 Zabrze, PolandDepartment of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Wolynska St. 35, 60-637 Poznan, PolandFood contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to the neurotoxicity of these toxins. Based on the latest literature data, we presented the association of common <i>Fusarium</i> mycotoxins with neurological diseases. Articles from 2001 to 2024 were analyzed. The mechanisms underlying the neurotoxicity of the described mycotoxins were presented. They are mainly related to the increase in oxidative stress in neuronal cells, which leads to higher levels of pro-inflammatory cytokines as IL-1β, IL-6 and TNF-α, enzymatic activity as GST, GPx, CAT and SOD and neurotransmitter dysfunction (5-HT, serotonin, dopamine and GABA). At the end of the article, based on the literature data, we attempted to present ways to mitigate mycotoxin neurotoxicity using mainly natural substances of plant origin. The data in this review focus on the <i>Fusarium</i> mycotoxins most frequently found in food and will be useful as comparative information for future studies. It is important to conduct further studies to mitigate the neurotoxic effects of <i>Fusarium</i> mycotoxins in order to reduce the development of diseases of the nervous system.https://www.mdpi.com/2072-6651/17/1/24neurotoxicitymycotoxins<i>Fusarium</i> spp.<i>Penicillium</i> spp.<i>Aspergillus</i> spp. protection |
| spellingShingle | Aleksandra Kuć-Szymanek Daria Kubik-Machura Klaudia Kościelecka Tomasz Męcik-Kronenberg Lidia Radko Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection Toxins neurotoxicity mycotoxins <i>Fusarium</i> spp. <i>Penicillium</i> spp. <i>Aspergillus</i> spp. protection |
| title | Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection |
| title_full | Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection |
| title_fullStr | Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection |
| title_full_unstemmed | Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection |
| title_short | Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection |
| title_sort | neurotoxicological effects of some mycotoxins on humans health and methods of neuroprotection |
| topic | neurotoxicity mycotoxins <i>Fusarium</i> spp. <i>Penicillium</i> spp. <i>Aspergillus</i> spp. protection |
| url | https://www.mdpi.com/2072-6651/17/1/24 |
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