Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway

Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway

Ethnopharmacological relevanceCelastrol, a bioactive compound from Tripterygium wilfordii Hook.f., is known for its anti-inflammatory and immunomodulatory effects, but its immunotoxicity is underexplored. This study investigates the mechanisms of celastrol-induced immunotoxicity, focusing on the PI3...

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Bibliographic Details
Main Authors: Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
celastrol
immunotoxicity
PI3K-Akt signaling pathway
network toxicology
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1567193/full
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