The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a clinical syndrome that manifests as acute deterioration of liver function due to a series of etiologies and triggers in patients with pre-existing chronic liver diseases. Systemic inflammatory response is the major feature of ACLF. Gut microbiota dysbiosis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1608137/full |
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| _version_ | 1849706557051240448 |
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| author | Xiaojing Qin Shuang Wang Zhanyao Yan Ninghui Zhao Jia Yao |
| author_facet | Xiaojing Qin Shuang Wang Zhanyao Yan Ninghui Zhao Jia Yao |
| author_sort | Xiaojing Qin |
| collection | DOAJ |
| description | Acute-on-chronic liver failure (ACLF) is a clinical syndrome that manifests as acute deterioration of liver function due to a series of etiologies and triggers in patients with pre-existing chronic liver diseases. Systemic inflammatory response is the major feature of ACLF. Gut microbiota dysbiosis impairs the intestinal barrier, facilitating the translocation of microorganisms and their metabolites into the liver and thereby exacerbating liver inflammation and disease progression. Recent studies have revealed that bacterial outer membrane vesicles (OMVs) derived from gut microbiota act as key mediators in microbiota-host cell communication. This article elucidates the possible roles of OMVs in ACLF inflammation and their underlying mechanisms. |
| format | Article |
| id | doaj-art-e6cb7e0e7ff842529e63a1f8471b816d |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-e6cb7e0e7ff842529e63a1f8471b816d2025-08-20T03:16:10ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-07-011610.3389/fmicb.2025.16081371608137The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failureXiaojing QinShuang WangZhanyao YanNinghui ZhaoJia YaoAcute-on-chronic liver failure (ACLF) is a clinical syndrome that manifests as acute deterioration of liver function due to a series of etiologies and triggers in patients with pre-existing chronic liver diseases. Systemic inflammatory response is the major feature of ACLF. Gut microbiota dysbiosis impairs the intestinal barrier, facilitating the translocation of microorganisms and their metabolites into the liver and thereby exacerbating liver inflammation and disease progression. Recent studies have revealed that bacterial outer membrane vesicles (OMVs) derived from gut microbiota act as key mediators in microbiota-host cell communication. This article elucidates the possible roles of OMVs in ACLF inflammation and their underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1608137/fullacute-on-chronic liver failurebacteriaouter membrane vesiclesinflammationcirrhosisgut-liver axis |
| spellingShingle | Xiaojing Qin Shuang Wang Zhanyao Yan Ninghui Zhao Jia Yao The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure Frontiers in Microbiology acute-on-chronic liver failure bacteria outer membrane vesicles inflammation cirrhosis gut-liver axis |
| title | The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure |
| title_full | The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure |
| title_fullStr | The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure |
| title_full_unstemmed | The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure |
| title_short | The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure |
| title_sort | role of bacterial outer membrane vesicles in inflammatory response of acute on chronic liver failure |
| topic | acute-on-chronic liver failure bacteria outer membrane vesicles inflammation cirrhosis gut-liver axis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1608137/full |
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