Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia
Pneumonia is a severe lower respiratory tract infection. This study demonstrates that phospholipase A2 (PLA2), a potential biomarker for pneumonia, contributes to alveoli damage by hydrolyzing pulmonary surfactant phospholipids. This process impairs gas exchange and generates hemolytic phospholipids...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/7/516 |
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| author | Jianyu Wang Huanchun Xing Lin Wang Zhongxing Xu Xin Sui Yuan Luo Jun Yang Yongan Wang |
| author_facet | Jianyu Wang Huanchun Xing Lin Wang Zhongxing Xu Xin Sui Yuan Luo Jun Yang Yongan Wang |
| author_sort | Jianyu Wang |
| collection | DOAJ |
| description | Pneumonia is a severe lower respiratory tract infection. This study demonstrates that phospholipase A2 (PLA2), a potential biomarker for pneumonia, contributes to alveoli damage by hydrolyzing pulmonary surfactant phospholipids. This process impairs gas exchange and generates hemolytic phospholipids that disrupt cellular membranes, exacerbating pulmonary injury. Experimental evidence demonstrates that PLA2 inhibitors significantly alleviate cellular damage in lipopolysaccharide (LPS)-induced pulmonary inflammation. These findings reveal a key mechanistic role of PLA2 in pneumonia pathogenesis and suggest novel therapeutic strategies. The results may provide more effective clinical interventions and guide further research in related fields. |
| format | Article |
| id | doaj-art-e6c7b08cec7545cebc1fd204e03082d9 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-e6c7b08cec7545cebc1fd204e03082d92025-08-20T03:35:27ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-07-0147751610.3390/cimb47070516Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for PneumoniaJianyu Wang0Huanchun Xing1Lin Wang2Zhongxing Xu3Xin Sui4Yuan Luo5Jun Yang6Yongan Wang7State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, ChinaPneumonia is a severe lower respiratory tract infection. This study demonstrates that phospholipase A2 (PLA2), a potential biomarker for pneumonia, contributes to alveoli damage by hydrolyzing pulmonary surfactant phospholipids. This process impairs gas exchange and generates hemolytic phospholipids that disrupt cellular membranes, exacerbating pulmonary injury. Experimental evidence demonstrates that PLA2 inhibitors significantly alleviate cellular damage in lipopolysaccharide (LPS)-induced pulmonary inflammation. These findings reveal a key mechanistic role of PLA2 in pneumonia pathogenesis and suggest novel therapeutic strategies. The results may provide more effective clinical interventions and guide further research in related fields.https://www.mdpi.com/1467-3045/47/7/516pneumoniaalveolar surfactantlipopolysaccharidesphospholipase A2 inhibitoralveolar macrophagesantibiotic resistance |
| spellingShingle | Jianyu Wang Huanchun Xing Lin Wang Zhongxing Xu Xin Sui Yuan Luo Jun Yang Yongan Wang Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia Current Issues in Molecular Biology pneumonia alveolar surfactant lipopolysaccharides phospholipase A2 inhibitor alveolar macrophages antibiotic resistance |
| title | Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia |
| title_full | Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia |
| title_fullStr | Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia |
| title_full_unstemmed | Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia |
| title_short | Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia |
| title_sort | inhibiting the interaction between phospholipase a2 and phospholipid serine as a potential therapeutic method for pneumonia |
| topic | pneumonia alveolar surfactant lipopolysaccharides phospholipase A2 inhibitor alveolar macrophages antibiotic resistance |
| url | https://www.mdpi.com/1467-3045/47/7/516 |
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