Dobutamine in paediatric population: a systematic review in juvenile animal models.
<h4>Objective</h4>Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals to determine whether the evidence from juvenile animal expe...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095644&type=printable |
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| author | Victoria Mielgo Adolf Valls i Soler Carmen Rey-Santano |
| author_facet | Victoria Mielgo Adolf Valls i Soler Carmen Rey-Santano |
| author_sort | Victoria Mielgo |
| collection | DOAJ |
| description | <h4>Objective</h4>Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals to determine whether the evidence from juvenile animal experiments with dobutamine supported the design of clinical trials in neonatal/paediatric population.<h4>Methods</h4>Studies were identified by searching MEDLINE (1946-2012) and EMBASE (1974-2012). Articles retrieved were independently reviewed by three authors and only those concerning efficacy and safety of the drug in juvenile animals were included. Only original articles published in English and Spanish were included.<h4>Results</h4>Following our literature search, 265 articles were retrieved and 24 studies were included in the review: 17 focused on neonatal models and 7 on young animal models. Although the aims and design of these studies, as well as the doses and ages analysed, were quite heterogeneous, the majority of authors agree that dobutamine infusion improves cardiac output in a dose dependent manner. Moreover, the cardiovascular effects of dobutamine are influenced by postnatal age, as well as by the dose used and the duration of the therapy. There is inadequate information about the effects of dobutamine on cerebral perfusion to draw conclusions.<h4>Conclusion</h4>There is enough preclinical evidence to ensure that dobutamine improves cardiac output, however to better understand its effects in peripheral organs, such as the brain, more specific and well designed studies are required to provide additional data to support the design of clinical trials in a paediatric population. |
| format | Article |
| id | doaj-art-e6c3bc50566e4a1c85f769403fe6fc63 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-e6c3bc50566e4a1c85f769403fe6fc632025-08-20T03:09:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9564410.1371/journal.pone.0095644Dobutamine in paediatric population: a systematic review in juvenile animal models.Victoria MielgoAdolf Valls i SolerCarmen Rey-Santano<h4>Objective</h4>Although dobutamine is widely used in neonatal clinical practice, the evidence for its use in this specific population is not clear. We conducted a systematic review of the use of dobutamine in juvenile animals to determine whether the evidence from juvenile animal experiments with dobutamine supported the design of clinical trials in neonatal/paediatric population.<h4>Methods</h4>Studies were identified by searching MEDLINE (1946-2012) and EMBASE (1974-2012). Articles retrieved were independently reviewed by three authors and only those concerning efficacy and safety of the drug in juvenile animals were included. Only original articles published in English and Spanish were included.<h4>Results</h4>Following our literature search, 265 articles were retrieved and 24 studies were included in the review: 17 focused on neonatal models and 7 on young animal models. Although the aims and design of these studies, as well as the doses and ages analysed, were quite heterogeneous, the majority of authors agree that dobutamine infusion improves cardiac output in a dose dependent manner. Moreover, the cardiovascular effects of dobutamine are influenced by postnatal age, as well as by the dose used and the duration of the therapy. There is inadequate information about the effects of dobutamine on cerebral perfusion to draw conclusions.<h4>Conclusion</h4>There is enough preclinical evidence to ensure that dobutamine improves cardiac output, however to better understand its effects in peripheral organs, such as the brain, more specific and well designed studies are required to provide additional data to support the design of clinical trials in a paediatric population.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095644&type=printable |
| spellingShingle | Victoria Mielgo Adolf Valls i Soler Carmen Rey-Santano Dobutamine in paediatric population: a systematic review in juvenile animal models. PLoS ONE |
| title | Dobutamine in paediatric population: a systematic review in juvenile animal models. |
| title_full | Dobutamine in paediatric population: a systematic review in juvenile animal models. |
| title_fullStr | Dobutamine in paediatric population: a systematic review in juvenile animal models. |
| title_full_unstemmed | Dobutamine in paediatric population: a systematic review in juvenile animal models. |
| title_short | Dobutamine in paediatric population: a systematic review in juvenile animal models. |
| title_sort | dobutamine in paediatric population a systematic review in juvenile animal models |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095644&type=printable |
| work_keys_str_mv | AT victoriamielgo dobutamineinpaediatricpopulationasystematicreviewinjuvenileanimalmodels AT adolfvallsisoler dobutamineinpaediatricpopulationasystematicreviewinjuvenileanimalmodels AT carmenreysantano dobutamineinpaediatricpopulationasystematicreviewinjuvenileanimalmodels |