QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE
Objective: to study whether myocardial single-photon emission computed tomography (SPECT)/CT with radiation absorption correction (RAC) versus fractional flow reserve (FFR) may be used to assess the hemodynamic relevance of borderline coronary stenosis in patients with coronary heart disease (CHD).M...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Luchevaya Diagnostika, LLC
2016-02-01
|
| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/57 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849245557501984768 |
|---|---|
| author | V. V. Solomyanyy I. V. Sergienko A. N. Samko |
| author_facet | V. V. Solomyanyy I. V. Sergienko A. N. Samko |
| author_sort | V. V. Solomyanyy |
| collection | DOAJ |
| description | Objective: to study whether myocardial single-photon emission computed tomography (SPECT)/CT with radiation absorption correction (RAC) versus fractional flow reserve (FFR) may be used to assess the hemodynamic relevance of borderline coronary stenosis in patients with coronary heart disease (CHD).Material and methods. The investigation enrolled 70 patients (50 men and 20 women; mean age 57±5 years) diagnosed as having CHD verified by clinical instrumental studies, in whom coronary angiography (CA) estimating FFR revealed 50 to 70% coronary stenosis; then all the patients underwent SPECT/CT using a two-day rest/ exercise (bicycle ergometer) protocol; the total injected radiotracer activity was 370–900 MBq 99mTc-MIBI depending on body weight.Results. A standard 17-segment scheme was employed to calculate the SDS index, borderline stenosis detected by CA was considered hemodynamically significant at SDS≥4 in one of the 17 segments, which corresponded to one of the major coronary artery, which was compared by the authors with FFR. At SDS≥4, the sensitivity and specificity of SPECT/CT were shown to be 96.7 and 90.6%, respectively.Conclusion. Quantitative analysis of borderline stenosis by SPECT/CT with RAC increases its specificity and sensitivity in estimating the functional significance of borderline coronary stenosis. |
| format | Article |
| id | doaj-art-e6bef63061ac46079c58ec227a20f74d |
| institution | Kabale University |
| issn | 0042-4676 2619-0478 |
| language | English |
| publishDate | 2016-02-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj-art-e6bef63061ac46079c58ec227a20f74d2025-08-20T03:58:45ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782016-02-0106394610.20862/0042-4676-2014-0-6-39-4657QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVEV. V. Solomyanyy0I. V. Sergienko1A. N. Samko2Russian Cardiology Research-and-Production Complex, Ministry of Health of the RFRussian Cardiology Research-and-Production Complex, Ministry of Health of the RFRussian Cardiology Research-and-Production Complex, Ministry of Health of the RFObjective: to study whether myocardial single-photon emission computed tomography (SPECT)/CT with radiation absorption correction (RAC) versus fractional flow reserve (FFR) may be used to assess the hemodynamic relevance of borderline coronary stenosis in patients with coronary heart disease (CHD).Material and methods. The investigation enrolled 70 patients (50 men and 20 women; mean age 57±5 years) diagnosed as having CHD verified by clinical instrumental studies, in whom coronary angiography (CA) estimating FFR revealed 50 to 70% coronary stenosis; then all the patients underwent SPECT/CT using a two-day rest/ exercise (bicycle ergometer) protocol; the total injected radiotracer activity was 370–900 MBq 99mTc-MIBI depending on body weight.Results. A standard 17-segment scheme was employed to calculate the SDS index, borderline stenosis detected by CA was considered hemodynamically significant at SDS≥4 in one of the 17 segments, which corresponded to one of the major coronary artery, which was compared by the authors with FFR. At SDS≥4, the sensitivity and specificity of SPECT/CT were shown to be 96.7 and 90.6%, respectively.Conclusion. Quantitative analysis of borderline stenosis by SPECT/CT with RAC increases its specificity and sensitivity in estimating the functional significance of borderline coronary stenosis.https://www.russianradiology.ru/jour/article/view/57coronary heart diseaseborderline coronary stenosissingle-photon emission computed tomographyradiation absorption correctionfractional flow reservequantitative myocardial perfusion parameters |
| spellingShingle | V. V. Solomyanyy I. V. Sergienko A. N. Samko QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE Вестник рентгенологии и радиологии coronary heart disease borderline coronary stenosis single-photon emission computed tomography radiation absorption correction fractional flow reserve quantitative myocardial perfusion parameters |
| title | QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE |
| title_full | QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE |
| title_fullStr | QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE |
| title_full_unstemmed | QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE |
| title_short | QUANTITATIVE ASSESSMENT OF THE HEMODYNAMIC RELEVANCE OF BORDERLINE CORONARY STENOSES BY MYOCARDIAL SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH RADIATION ABSORPTION CORRECTION VERSUS FRACTIONAL FLOW RESERVE |
| title_sort | quantitative assessment of the hemodynamic relevance of borderline coronary stenoses by myocardial single photon emission computed tomography with radiation absorption correction versus fractional flow reserve |
| topic | coronary heart disease borderline coronary stenosis single-photon emission computed tomography radiation absorption correction fractional flow reserve quantitative myocardial perfusion parameters |
| url | https://www.russianradiology.ru/jour/article/view/57 |
| work_keys_str_mv | AT vvsolomyanyy quantitativeassessmentofthehemodynamicrelevanceofborderlinecoronarystenosesbymyocardialsinglephotonemissioncomputedtomographywithradiationabsorptioncorrectionversusfractionalflowreserve AT ivsergienko quantitativeassessmentofthehemodynamicrelevanceofborderlinecoronarystenosesbymyocardialsinglephotonemissioncomputedtomographywithradiationabsorptioncorrectionversusfractionalflowreserve AT ansamko quantitativeassessmentofthehemodynamicrelevanceofborderlinecoronarystenosesbymyocardialsinglephotonemissioncomputedtomographywithradiationabsorptioncorrectionversusfractionalflowreserve |