Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil
The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum m...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/9/12/310 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239204546576384 |
|---|---|
| author | Cristiane Tiburtino de Oliveira Gomes Carolline Araujo Mariz Andrea Dória Batista Clarice Neuenschwander Lins de Morais Lílian Araújo Ana Virgínia Matos Sá Barreto Michele Soares Gomes-Gouvêa Ana Lúcia Domingues Edmundo Pessoa Lopes |
| author_facet | Cristiane Tiburtino de Oliveira Gomes Carolline Araujo Mariz Andrea Dória Batista Clarice Neuenschwander Lins de Morais Lílian Araújo Ana Virgínia Matos Sá Barreto Michele Soares Gomes-Gouvêa Ana Lúcia Domingues Edmundo Pessoa Lopes |
| author_sort | Cristiane Tiburtino de Oliveira Gomes |
| collection | DOAJ |
| description | The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum markers and ultrasound criteria. This cross-sectional study was carried out in an endemic area in Pernambuco, Brazil, with schistosomal patients who underwent coproscopic survey. Anti-HEV antibody IgG were evaluated by using ELISA (Euroimmun<sup>®,</sup> Lübeck, Germmany). In positive cases, HEV-RNA was tested by using real-time PCR. Among the 286 patients (60.8% women; 56% 18–44 years), 116 (40.6%) had advanced PPF (Niamey pattern D/E/F). Anti-HEV IgG was positive in 15 (5.24%), and all were HEV-RNA negative. Anti-HEV IgG was more frequent in patients with an advanced PPF (D/E/F) pattern (<i>p</i> = 0.034) and those with the largest spleen diameter (<i>p</i> = 0.039). In this study, the occurrence of anti-HEV IgG in patients with SM was higher than described in the same region and more frequent among patients with evidence of advanced liver fibrosis. |
| format | Article |
| id | doaj-art-e6bd40ee628349dd90b94725a288a0e7 |
| institution | OA Journals |
| issn | 2414-6366 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-e6bd40ee628349dd90b94725a288a0e72025-08-20T02:01:14ZengMDPI AGTropical Medicine and Infectious Disease2414-63662024-12-0191231010.3390/tropicalmed9120310Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in BrazilCristiane Tiburtino de Oliveira Gomes0Carolline Araujo Mariz1Andrea Dória Batista2Clarice Neuenschwander Lins de Morais3Lílian Araújo4Ana Virgínia Matos Sá Barreto5Michele Soares Gomes-Gouvêa6Ana Lúcia Domingues7Edmundo Pessoa Lopes8Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50670-420, PE, BrazilDepartment of Parasitology, Aggeu Magalhães Institute, Fiocruz, Recife 50740-465, PE, BrazilGastroenterology Division, Hospital das Clínicas/EBSERH, Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, BrazilDepartment of Virology, Aggeu Magalhães Institute, Fiocruz, Recife 50740-465, PE, BrazilGastroenterology Division, Hospital das Clínicas/EBSERH, Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, BrazilDepartment of Health, Maurício de Nassau University Center, Recife 51021-140, PE, BrazilLaboratory of Gastroenterology and Tropical Hepatology (LIM-07), Institute of Tropical Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, SP, BrazilPostgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50670-420, PE, BrazilPostgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50670-420, PE, BrazilThe occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum markers and ultrasound criteria. This cross-sectional study was carried out in an endemic area in Pernambuco, Brazil, with schistosomal patients who underwent coproscopic survey. Anti-HEV antibody IgG were evaluated by using ELISA (Euroimmun<sup>®,</sup> Lübeck, Germmany). In positive cases, HEV-RNA was tested by using real-time PCR. Among the 286 patients (60.8% women; 56% 18–44 years), 116 (40.6%) had advanced PPF (Niamey pattern D/E/F). Anti-HEV IgG was positive in 15 (5.24%), and all were HEV-RNA negative. Anti-HEV IgG was more frequent in patients with an advanced PPF (D/E/F) pattern (<i>p</i> = 0.034) and those with the largest spleen diameter (<i>p</i> = 0.039). In this study, the occurrence of anti-HEV IgG in patients with SM was higher than described in the same region and more frequent among patients with evidence of advanced liver fibrosis.https://www.mdpi.com/2414-6366/9/12/310anti-HEVcoinfectionhepatic fibrosishepatitis E virusSchistosomiasis mansoni |
| spellingShingle | Cristiane Tiburtino de Oliveira Gomes Carolline Araujo Mariz Andrea Dória Batista Clarice Neuenschwander Lins de Morais Lílian Araújo Ana Virgínia Matos Sá Barreto Michele Soares Gomes-Gouvêa Ana Lúcia Domingues Edmundo Pessoa Lopes Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil Tropical Medicine and Infectious Disease anti-HEV coinfection hepatic fibrosis hepatitis E virus Schistosomiasis mansoni |
| title | Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil |
| title_full | Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil |
| title_fullStr | Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil |
| title_full_unstemmed | Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil |
| title_short | Seroprevalence of Hepatitis E Virus Among Schistosomiasis mansoni Patients Residing in Endemic Zone in Brazil |
| title_sort | seroprevalence of hepatitis e virus among schistosomiasis mansoni patients residing in endemic zone in brazil |
| topic | anti-HEV coinfection hepatic fibrosis hepatitis E virus Schistosomiasis mansoni |
| url | https://www.mdpi.com/2414-6366/9/12/310 |
| work_keys_str_mv | AT cristianetiburtinodeoliveiragomes seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT carollinearaujomariz seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT andreadoriabatista seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT clariceneuenschwanderlinsdemorais seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT lilianaraujo seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT anavirginiamatossabarreto seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT michelesoaresgomesgouvea seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT analuciadomingues seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil AT edmundopessoalopes seroprevalenceofhepatitisevirusamongschistosomiasismansonipatientsresidinginendemiczoneinbrazil |