Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs
Hybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate (NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and lox...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Chemical Engineering |
| Online Access: | http://dx.doi.org/10.1155/2012/832190 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467886206189568 |
|---|---|
| author | Na Wang Mengbing Cui Cuiming Wu Yiyun Cheng Tongwen Xu |
| author_facet | Na Wang Mengbing Cui Cuiming Wu Yiyun Cheng Tongwen Xu |
| author_sort | Na Wang |
| collection | DOAJ |
| description | Hybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate (NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and loxoprofen (NaLS). The results of the static loading and release experiments suggest that electrostatic interaction, hydrogen bonding, and hydrophobic interaction are the main interaction patterns between the membrane and the drugs. And they are directly influenced by the external phase conditions and the drug physicochemical characteristics, such as structure, molecular weight, dissociation (pKa), and hydrogen bonding capability. Among the four different drugs, NaSA and NaMAS appear to be the most suitable for controlled release by the HAEHFM due to their excellent adsorption/release behaviors. |
| format | Article |
| id | doaj-art-e6b8659d4de24d4f8e9b0b6a9c25acd2 |
| institution | Kabale University |
| issn | 1687-806X 1687-8078 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Chemical Engineering |
| spelling | doaj-art-e6b8659d4de24d4f8e9b0b6a9c25acd22025-08-20T03:26:00ZengWileyInternational Journal of Chemical Engineering1687-806X1687-80782012-01-01201210.1155/2012/832190832190Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic DrugsNa Wang0Mengbing Cui1Cuiming Wu2Yiyun Cheng3Tongwen Xu4Laboratory of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei 230026, ChinaLaboratory of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei 230026, ChinaSchool of Chemical Engineering, Hefei University of Technology, Hefei 230009, ChinaSchool of Life Sciences, East China Normal University, Shanghai 200062, ChinaLaboratory of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei 230026, ChinaHybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate (NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and loxoprofen (NaLS). The results of the static loading and release experiments suggest that electrostatic interaction, hydrogen bonding, and hydrophobic interaction are the main interaction patterns between the membrane and the drugs. And they are directly influenced by the external phase conditions and the drug physicochemical characteristics, such as structure, molecular weight, dissociation (pKa), and hydrogen bonding capability. Among the four different drugs, NaSA and NaMAS appear to be the most suitable for controlled release by the HAEHFM due to their excellent adsorption/release behaviors.http://dx.doi.org/10.1155/2012/832190 |
| spellingShingle | Na Wang Mengbing Cui Cuiming Wu Yiyun Cheng Tongwen Xu Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs International Journal of Chemical Engineering |
| title | Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs |
| title_full | Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs |
| title_fullStr | Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs |
| title_full_unstemmed | Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs |
| title_short | Hybrid Anion Exchange Hollow Fiber Membrane for Delivery of Ionic Drugs |
| title_sort | hybrid anion exchange hollow fiber membrane for delivery of ionic drugs |
| url | http://dx.doi.org/10.1155/2012/832190 |
| work_keys_str_mv | AT nawang hybridanionexchangehollowfibermembranefordeliveryofionicdrugs AT mengbingcui hybridanionexchangehollowfibermembranefordeliveryofionicdrugs AT cuimingwu hybridanionexchangehollowfibermembranefordeliveryofionicdrugs AT yiyuncheng hybridanionexchangehollowfibermembranefordeliveryofionicdrugs AT tongwenxu hybridanionexchangehollowfibermembranefordeliveryofionicdrugs |