Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis
Abstract Coronary microvascular disease (CMVD) is associated with abnormalities in glucose-lipid metabolism. And the triglyceride to high density lipoprotein (HDL) (TG/HDL) ratio can be used to characterize levels of glycolipid metabolism. Therefore, it is hypothesized that increased TG/HDL may trig...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-08057-4 |
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| author | Wei Wen Yi Chi Mingwang Liu Mengjie Gao Beili Xie Yuxin Yan Zhidie Jin Lulian Jiang Yiqing Zhang Keji Chen Fuhai Zhao |
| author_facet | Wei Wen Yi Chi Mingwang Liu Mengjie Gao Beili Xie Yuxin Yan Zhidie Jin Lulian Jiang Yiqing Zhang Keji Chen Fuhai Zhao |
| author_sort | Wei Wen |
| collection | DOAJ |
| description | Abstract Coronary microvascular disease (CMVD) is associated with abnormalities in glucose-lipid metabolism. And the triglyceride to high density lipoprotein (HDL) (TG/HDL) ratio can be used to characterize levels of glycolipid metabolism. Therefore, it is hypothesized that increased TG/HDL may trigger CMVD. This study enrolled patients with angina pectoris but negative coronary angiograms to explore inflammatory factor-mediated disorder of glycolipid metabolism triggers CMVD. Logistics regression model and subgroup analysis were constructed to explore the associations between TG/HDL and CMVD. Restricted cubic splines were applied to further the associations of TG/HDL with CMVD. Given inflammatory factors as intermediary factor, we investigate the mediating effects of TG/HDL on CMVD. 242 patients were eventually recruited and 150 patients were diagnosed with CMVD. In the multivariable-adjusted model, TG/HDL and inflammatory indexes including the C-reaction protein (CRP), C-reaction protein to lymphocyte ratio (CLR) and inflammatory burden index (IBI) were positively related to CMVD (Odds Ratio (OR) = 1.71, 95% CI = 0.69–4.25; OR = 1.89, 95% CI = 1.32–2.68; OR = 2.76, 95% CI = 1.56–4.89; OR = 1.22, 95% CI = 1.08–1.37, respectively). Mediation analysis indicated that CRP, CLR and IBI mediated 26.37%, 16.89% and 10.45% of the association of TG/HDL with CMVD. TG/HDL is positively associated with CMVD. And this association appeared to be partially mediated through inflammatory indices. |
| format | Article |
| id | doaj-art-e6b76b7d7ac64258ae84ad38fc46bec8 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e6b76b7d7ac64258ae84ad38fc46bec82025-08-20T04:01:24ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-08057-4Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesisWei Wen0Yi Chi1Mingwang Liu2Mengjie Gao3Beili Xie4Yuxin Yan5Zhidie Jin6Lulian Jiang7Yiqing Zhang8Keji Chen9Fuhai Zhao10Xiyuan Hospital of China Academy of Chinese Medical SciencesThe People’s Hospital of Xianqzhou DistrictXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesThe People’s Hospital of Xianqzhou DistrictXiyuan Hospital of China Academy of Chinese Medical SciencesXiyuan Hospital of China Academy of Chinese Medical SciencesAbstract Coronary microvascular disease (CMVD) is associated with abnormalities in glucose-lipid metabolism. And the triglyceride to high density lipoprotein (HDL) (TG/HDL) ratio can be used to characterize levels of glycolipid metabolism. Therefore, it is hypothesized that increased TG/HDL may trigger CMVD. This study enrolled patients with angina pectoris but negative coronary angiograms to explore inflammatory factor-mediated disorder of glycolipid metabolism triggers CMVD. Logistics regression model and subgroup analysis were constructed to explore the associations between TG/HDL and CMVD. Restricted cubic splines were applied to further the associations of TG/HDL with CMVD. Given inflammatory factors as intermediary factor, we investigate the mediating effects of TG/HDL on CMVD. 242 patients were eventually recruited and 150 patients were diagnosed with CMVD. In the multivariable-adjusted model, TG/HDL and inflammatory indexes including the C-reaction protein (CRP), C-reaction protein to lymphocyte ratio (CLR) and inflammatory burden index (IBI) were positively related to CMVD (Odds Ratio (OR) = 1.71, 95% CI = 0.69–4.25; OR = 1.89, 95% CI = 1.32–2.68; OR = 2.76, 95% CI = 1.56–4.89; OR = 1.22, 95% CI = 1.08–1.37, respectively). Mediation analysis indicated that CRP, CLR and IBI mediated 26.37%, 16.89% and 10.45% of the association of TG/HDL with CMVD. TG/HDL is positively associated with CMVD. And this association appeared to be partially mediated through inflammatory indices.https://doi.org/10.1038/s41598-025-08057-4Coronary microvascular diseaseC-reaction proteinC-reaction protein to lymphocyte ratioInflammatory burden indexTriglyceride to high density lipoprotein |
| spellingShingle | Wei Wen Yi Chi Mingwang Liu Mengjie Gao Beili Xie Yuxin Yan Zhidie Jin Lulian Jiang Yiqing Zhang Keji Chen Fuhai Zhao Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis Scientific Reports Coronary microvascular disease C-reaction protein C-reaction protein to lymphocyte ratio Inflammatory burden index Triglyceride to high density lipoprotein |
| title | Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| title_full | Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| title_fullStr | Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| title_full_unstemmed | Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| title_short | Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| title_sort | inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis |
| topic | Coronary microvascular disease C-reaction protein C-reaction protein to lymphocyte ratio Inflammatory burden index Triglyceride to high density lipoprotein |
| url | https://doi.org/10.1038/s41598-025-08057-4 |
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