Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study
Background: The influence of air pollution on osteoarthritis (OA) remains underexplored. Methods: We conducted a prospective cohort study in the UK Biobank, estimating exposure levels of particulate matter (PM2.5, PM10, PM2.5–10), nitrogen oxides (NO2, NOx), and air pollutants exposure score (APES)....
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500106X |
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| author | Jing Qian Jiahao Zhu Yifan Wang Ruoqi Dai Jingyou Miao Ye Yang Wenxia Zhao Jing Wang Lilu Ding Dan Zhou Min Yu Yingjun Li |
| author_facet | Jing Qian Jiahao Zhu Yifan Wang Ruoqi Dai Jingyou Miao Ye Yang Wenxia Zhao Jing Wang Lilu Ding Dan Zhou Min Yu Yingjun Li |
| author_sort | Jing Qian |
| collection | DOAJ |
| description | Background: The influence of air pollution on osteoarthritis (OA) remains underexplored. Methods: We conducted a prospective cohort study in the UK Biobank, estimating exposure levels of particulate matter (PM2.5, PM10, PM2.5–10), nitrogen oxides (NO2, NOx), and air pollutants exposure score (APES). Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival. Additionally, using genome-wide association statistics, we examined the potential causal associations between air pollution-related DNA methylation (DNAm) and OA risk. Gene-environment interaction analyses were conducted to explore the potential modification effect of DNA methylation-related genetic variants on the impact of air pollution on OA risk. Results: Individual exposure to each air pollutant was associated with an increased risk of developing OA, but not with progression from OA to joint replacement. For APES, the hazard ratio for incident OA was 1.09 (95 % CI = 1.04–1.13), and the hazard ratio of progression from OA to death was 1.16 (95 % CI = 1.00–1.35) in the highest quartile group compared to the lowest quartile group. Moreover, genetically predicted methylation at the PM2.5-related CpG site cg04027612 near the GDF5 gene was associated with a lower risk of OA. A potential epigenetic modification effect of cg04027612 near GDF5 on OA risk was observed. Conclusion: Long-term exposure to air pollution was associated with an increased risk of OA in the population and poorer survival outcomes for OA patients, with epigenetic changes in GDF5 potentially playing a role in the underlying mechanisms. |
| format | Article |
| id | doaj-art-e6b6010ef3f743a0a638c36b8359cdf3 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e6b6010ef3f743a0a638c36b8359cdf32025-02-12T05:30:18ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117770Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort studyJing Qian0Jiahao Zhu1Yifan Wang2Ruoqi Dai3Jingyou Miao4Ye Yang5Wenxia Zhao6Jing Wang7Lilu Ding8Dan Zhou9Min Yu10Yingjun Li11Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Psychology, University of Toronto Scarborough, Toronto, CanadaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, ChinaSchool of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China; Correspondence to: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China.Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China; Correspondence to: Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, 481 Binwen Road, Hangzhou 310053, China.Background: The influence of air pollution on osteoarthritis (OA) remains underexplored. Methods: We conducted a prospective cohort study in the UK Biobank, estimating exposure levels of particulate matter (PM2.5, PM10, PM2.5–10), nitrogen oxides (NO2, NOx), and air pollutants exposure score (APES). Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival. Additionally, using genome-wide association statistics, we examined the potential causal associations between air pollution-related DNA methylation (DNAm) and OA risk. Gene-environment interaction analyses were conducted to explore the potential modification effect of DNA methylation-related genetic variants on the impact of air pollution on OA risk. Results: Individual exposure to each air pollutant was associated with an increased risk of developing OA, but not with progression from OA to joint replacement. For APES, the hazard ratio for incident OA was 1.09 (95 % CI = 1.04–1.13), and the hazard ratio of progression from OA to death was 1.16 (95 % CI = 1.00–1.35) in the highest quartile group compared to the lowest quartile group. Moreover, genetically predicted methylation at the PM2.5-related CpG site cg04027612 near the GDF5 gene was associated with a lower risk of OA. A potential epigenetic modification effect of cg04027612 near GDF5 on OA risk was observed. Conclusion: Long-term exposure to air pollution was associated with an increased risk of OA in the population and poorer survival outcomes for OA patients, with epigenetic changes in GDF5 potentially playing a role in the underlying mechanisms.http://www.sciencedirect.com/science/article/pii/S014765132500106XOsteoarthritisAir pollutionDNA methylationGene-environment interaction |
| spellingShingle | Jing Qian Jiahao Zhu Yifan Wang Ruoqi Dai Jingyou Miao Ye Yang Wenxia Zhao Jing Wang Lilu Ding Dan Zhou Min Yu Yingjun Li Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study Ecotoxicology and Environmental Safety Osteoarthritis Air pollution DNA methylation Gene-environment interaction |
| title | Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study |
| title_full | Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study |
| title_fullStr | Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study |
| title_full_unstemmed | Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study |
| title_short | Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study |
| title_sort | associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival insights from a prospective cohort study |
| topic | Osteoarthritis Air pollution DNA methylation Gene-environment interaction |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500106X |
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