The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients
Aim. To investigate lipid profile, lipoprotein (a) [Lp(а)] and apolipoprotein В-100 (apo В-100) levels in coronary heart disease (CHD) patients. To identify significant CHD predictors and their association with cholesterol (CH) and triglyceride (TG) levels. Material and methods. In total, 575 patien...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2006-10-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1260 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041474748514304 |
|---|---|
| author | G. G. Arabidze E. O. Skryabina I. G. Inaneishvili O. I. Afanasyeva |
| author_facet | G. G. Arabidze E. O. Skryabina I. G. Inaneishvili O. I. Afanasyeva |
| author_sort | G. G. Arabidze |
| collection | DOAJ |
| description | Aim. To investigate lipid profile, lipoprotein (a) [Lp(а)] and apolipoprotein В-100 (apo В-100) levels in coronary heart disease (CHD) patients. To identify significant CHD predictors and their association with cholesterol (CH) and triglyceride (TG) levels. Material and methods. In total, 575 patients (main group), aged 66,56±12,51 years, with verified CHD were included, as well as 86 individuals (control group), aged 55,47±11,47 years, without cardiovascular disease (CVD). Results. Levels of apo B-100 – 128,17 mg/dl (р<0,00001) and Lp(a) – 27,6 mg/dl (р<0,007) were significantly higher in all CHD patients than in control group. Lp(a) level was significantly higher in acute coronary syndrome (ACS) patients, comparing to control group (р<0,02). Increased apo B-100 leve, 130,9±46,5 mg/dl was a significant (р<0,00001) risk factor (RF) for ACS in CHD patients. There was a significant correlation between Lp(a) (р<0,00003) or apo B-100 (р<0,00001) levels and CH or TG concentrations in CHD individuals. Conclusion. Lp(a) and apo B-100 levels were significant RF for CHD (including acute myocardial infarction) development. Maximal concentration of Lp(a) was observed in CHD patients with hypercholesterolemia (HCH); maximal apo B-100 level – in CHD and hypertriglyceridemia participants. |
| format | Article |
| id | doaj-art-e6b4c6a29ec14ee085a36b2c47a302ca |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2006-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-e6b4c6a29ec14ee085a36b2c47a302ca2025-08-20T02:55:46Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-10-01551420971The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patientsG. G. Arabidze0E. O. Skryabina1I. G. Inaneishvili2O. I. Afanasyeva3Moscow State Medico-Stomatological University, State Federal Agency for Health and Social DevelopmentCity Clinical Hospital No. 19, Health Department of Moscow City AdministrationCity Clinical Hospital No. 19, Health Department of Moscow City AdministrationExperimental Cardiology Research Institute, Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development. MoscowAim. To investigate lipid profile, lipoprotein (a) [Lp(а)] and apolipoprotein В-100 (apo В-100) levels in coronary heart disease (CHD) patients. To identify significant CHD predictors and their association with cholesterol (CH) and triglyceride (TG) levels. Material and methods. In total, 575 patients (main group), aged 66,56±12,51 years, with verified CHD were included, as well as 86 individuals (control group), aged 55,47±11,47 years, without cardiovascular disease (CVD). Results. Levels of apo B-100 – 128,17 mg/dl (р<0,00001) and Lp(a) – 27,6 mg/dl (р<0,007) were significantly higher in all CHD patients than in control group. Lp(a) level was significantly higher in acute coronary syndrome (ACS) patients, comparing to control group (р<0,02). Increased apo B-100 leve, 130,9±46,5 mg/dl was a significant (р<0,00001) risk factor (RF) for ACS in CHD patients. There was a significant correlation between Lp(a) (р<0,00003) or apo B-100 (р<0,00001) levels and CH or TG concentrations in CHD individuals. Conclusion. Lp(a) and apo B-100 levels were significant RF for CHD (including acute myocardial infarction) development. Maximal concentration of Lp(a) was observed in CHD patients with hypercholesterolemia (HCH); maximal apo B-100 level – in CHD and hypertriglyceridemia participants.https://cardiovascular.elpub.ru/jour/article/view/1260coronary heart diseaseacute coronary syndromeapolipoprotein b-100lipoprotein (a)total cholesteroltriglycerides |
| spellingShingle | G. G. Arabidze E. O. Skryabina I. G. Inaneishvili O. I. Afanasyeva The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients Кардиоваскулярная терапия и профилактика coronary heart disease acute coronary syndrome apolipoprotein b-100 lipoprotein (a) total cholesterol triglycerides |
| title | The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| title_full | The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| title_fullStr | The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| title_full_unstemmed | The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| title_short | The role of increased lipoprotein (a) and apolipoprotein B-100 levels, and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| title_sort | role of increased lipoprotein a and apolipoprotein b 100 levels and their link to cholesterol and triglyceride concentration in coronary heart disease patients |
| topic | coronary heart disease acute coronary syndrome apolipoprotein b-100 lipoprotein (a) total cholesterol triglycerides |
| url | https://cardiovascular.elpub.ru/jour/article/view/1260 |
| work_keys_str_mv | AT ggarabidze theroleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT eoskryabina theroleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT iginaneishvili theroleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT oiafanasyeva theroleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT ggarabidze roleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT eoskryabina roleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT iginaneishvili roleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients AT oiafanasyeva roleofincreasedlipoproteinaandapolipoproteinb100levelsandtheirlinktocholesterolandtriglycerideconcentrationincoronaryheartdiseasepatients |