Age-specific gender differences in morphological parameters of intracranial aneurysms
BackgroundGender differences are shown to exist in the incidence and outcome of subarachnoid hemorrhage as well as in the formation and progression of intracranial aneurysms. However, few studies investigated the gender difference in the morphology of intracranial aneurysms.MethodsA total of 308 con...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1480652/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849702142369071104 |
|---|---|
| author | Jianyao Mao Yukui Li Xin Gao Zhangyu Li Xi Chen Guowei Tan Zhanxiang Wang Ping Zhong Sifang Chen Sifang Chen |
| author_facet | Jianyao Mao Yukui Li Xin Gao Zhangyu Li Xi Chen Guowei Tan Zhanxiang Wang Ping Zhong Sifang Chen Sifang Chen |
| author_sort | Jianyao Mao |
| collection | DOAJ |
| description | BackgroundGender differences are shown to exist in the incidence and outcome of subarachnoid hemorrhage as well as in the formation and progression of intracranial aneurysms. However, few studies investigated the gender difference in the morphology of intracranial aneurysms.MethodsA total of 308 consecutive patients with 346 intracranial aneurysms from 2014 to 2020 were retrospectively analyzed. Differences in 10 morphological parameters of intracranial aneurysms between males and females were compared. Continuous variables were expressed as the median [interquartile range (IQR)] and the differences were analyzed using the Mann-Whitney test. Categorical variables were expressed as numbers (frequencies) and the differences were analyzed using χ2 test. Moreover, subgroup analyses were performed according to age stratifications: ≥60 years, 50–59 years, and <50 years.ResultsThe median aspect ratio maximum [1.38, IQR (1.17–1.83) vs. 1.27, IQR (1.00–1.57)], median aspect ratio [1.29, IQR (1.00–1.76) vs. 1.18, IQR (0.93–1.54)], median bottleneck factor [1.17, IQR (1.00–1.47) vs. 1.03, IQR (0.86–1.27)], and median volume-to-ostium area ratio [5.67, IQR (2.85–9.03) vs. 3.86, IQR (1.94–7.48)] in males were significantly higher than those in females (all P < 0.01). Particularly, the differences in the above morphological parameters between genders were most prominent in patients aged ≥ 60 years, whereas no differences were found in patients aged < 50 years. There were no significant differences in other morphological parameters between males and females, including neck width, transverse, height, maximum, aneurysm volume, and height-width ratio.ConclusionsGender difference existed in the morphology of intracranial aneurysms and was affected by age. The difference was prominent in patients aged ≥ 60 years, whereas no difference was found in patients aged < 50 years. |
| format | Article |
| id | doaj-art-e6b1c53e2cdc4284957e1b538a37ba74 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e6b1c53e2cdc4284957e1b538a37ba742025-08-20T03:17:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.14806521480652Age-specific gender differences in morphological parameters of intracranial aneurysmsJianyao Mao0Yukui Li1Xin Gao2Zhangyu Li3Xi Chen4Guowei Tan5Zhanxiang Wang6Ping Zhong7Sifang Chen8Sifang Chen9Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaBackgroundGender differences are shown to exist in the incidence and outcome of subarachnoid hemorrhage as well as in the formation and progression of intracranial aneurysms. However, few studies investigated the gender difference in the morphology of intracranial aneurysms.MethodsA total of 308 consecutive patients with 346 intracranial aneurysms from 2014 to 2020 were retrospectively analyzed. Differences in 10 morphological parameters of intracranial aneurysms between males and females were compared. Continuous variables were expressed as the median [interquartile range (IQR)] and the differences were analyzed using the Mann-Whitney test. Categorical variables were expressed as numbers (frequencies) and the differences were analyzed using χ2 test. Moreover, subgroup analyses were performed according to age stratifications: ≥60 years, 50–59 years, and <50 years.ResultsThe median aspect ratio maximum [1.38, IQR (1.17–1.83) vs. 1.27, IQR (1.00–1.57)], median aspect ratio [1.29, IQR (1.00–1.76) vs. 1.18, IQR (0.93–1.54)], median bottleneck factor [1.17, IQR (1.00–1.47) vs. 1.03, IQR (0.86–1.27)], and median volume-to-ostium area ratio [5.67, IQR (2.85–9.03) vs. 3.86, IQR (1.94–7.48)] in males were significantly higher than those in females (all P < 0.01). Particularly, the differences in the above morphological parameters between genders were most prominent in patients aged ≥ 60 years, whereas no differences were found in patients aged < 50 years. There were no significant differences in other morphological parameters between males and females, including neck width, transverse, height, maximum, aneurysm volume, and height-width ratio.ConclusionsGender difference existed in the morphology of intracranial aneurysms and was affected by age. The difference was prominent in patients aged ≥ 60 years, whereas no difference was found in patients aged < 50 years.https://www.frontiersin.org/articles/10.3389/fneur.2025.1480652/fullsubarachnoid hemorrhageintracranial aneurysmsgender differencemorphologyage |
| spellingShingle | Jianyao Mao Yukui Li Xin Gao Zhangyu Li Xi Chen Guowei Tan Zhanxiang Wang Ping Zhong Sifang Chen Sifang Chen Age-specific gender differences in morphological parameters of intracranial aneurysms Frontiers in Neurology subarachnoid hemorrhage intracranial aneurysms gender difference morphology age |
| title | Age-specific gender differences in morphological parameters of intracranial aneurysms |
| title_full | Age-specific gender differences in morphological parameters of intracranial aneurysms |
| title_fullStr | Age-specific gender differences in morphological parameters of intracranial aneurysms |
| title_full_unstemmed | Age-specific gender differences in morphological parameters of intracranial aneurysms |
| title_short | Age-specific gender differences in morphological parameters of intracranial aneurysms |
| title_sort | age specific gender differences in morphological parameters of intracranial aneurysms |
| topic | subarachnoid hemorrhage intracranial aneurysms gender difference morphology age |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1480652/full |
| work_keys_str_mv | AT jianyaomao agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT yukuili agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT xingao agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT zhangyuli agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT xichen agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT guoweitan agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT zhanxiangwang agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT pingzhong agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT sifangchen agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms AT sifangchen agespecificgenderdifferencesinmorphologicalparametersofintracranialaneurysms |