Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury
Abstract Background Spinal cord injury (SCI) arises from traumatic damage to the spinal cord, resulting in varying degrees of sensory, motor, and autonomic dysfunction. Mitochondria, as the primary energy-producing organelles within cells, have garnered increasing attention for their critical role i...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06611-2 |
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| author | Kaixuan Wang Xi Chen Mengmin Liu Yunjuan Li Yihua Zhu Tiantong Zhou Weiwei Tao Yong Ma Yang Guo Lining Wang Yue Hu |
| author_facet | Kaixuan Wang Xi Chen Mengmin Liu Yunjuan Li Yihua Zhu Tiantong Zhou Weiwei Tao Yong Ma Yang Guo Lining Wang Yue Hu |
| author_sort | Kaixuan Wang |
| collection | DOAJ |
| description | Abstract Background Spinal cord injury (SCI) arises from traumatic damage to the spinal cord, resulting in varying degrees of sensory, motor, and autonomic dysfunction. Mitochondria, as the primary energy-producing organelles within cells, have garnered increasing attention for their critical role in promoting axonal regeneration following SCI. Aim of review This review aims to systematically examine the alterations in mitochondrial dynamics post-SCI and to elucidate their influence on axonal regeneration. Furthermore, the review evaluates the current challenges associated with SCI treatment and proposes potential therapeutic strategies for future research. Key scientific concepts of review The review comprehensively addresses mitochondrial dynamics, with a focus on key processes such as biogenesis, fusion and fission, mitophagy, trafficking, and anchoring. It delves into the molecular mechanisms by which signaling pathways within neurons and glial cells regulate these mitochondrial processes to facilitate axonal regeneration. Additionally, the review identifies existing challenges in SCI treatment and advocates for targeted interventions in mitochondrial dynamics as a promising therapeutic avenue, offering significant potential for advancing future research and treatment of SCI. |
| format | Article |
| id | doaj-art-e6b1a1cf1e484030b79f2804d5ccd2d3 |
| institution | OA Journals |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-e6b1a1cf1e484030b79f2804d5ccd2d32025-08-20T02:05:14ZengBMCJournal of Translational Medicine1479-58762025-06-0123112610.1186/s12967-025-06611-2Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injuryKaixuan Wang0Xi Chen1Mengmin Liu2Yunjuan Li3Yihua Zhu4Tiantong Zhou5Weiwei Tao6Yong Ma7Yang Guo8Lining Wang9Yue Hu10School of Integrative Medicine, Nanjing University of Chinese MedicineSchool of Chinese Medicine, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineLaboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese MedicineSchool of Acupuncture-Moxibustion and Tuina, School of Health Preservation and Rehabilitation, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineSchool of Integrative Medicine, Nanjing University of Chinese MedicineAbstract Background Spinal cord injury (SCI) arises from traumatic damage to the spinal cord, resulting in varying degrees of sensory, motor, and autonomic dysfunction. Mitochondria, as the primary energy-producing organelles within cells, have garnered increasing attention for their critical role in promoting axonal regeneration following SCI. Aim of review This review aims to systematically examine the alterations in mitochondrial dynamics post-SCI and to elucidate their influence on axonal regeneration. Furthermore, the review evaluates the current challenges associated with SCI treatment and proposes potential therapeutic strategies for future research. Key scientific concepts of review The review comprehensively addresses mitochondrial dynamics, with a focus on key processes such as biogenesis, fusion and fission, mitophagy, trafficking, and anchoring. It delves into the molecular mechanisms by which signaling pathways within neurons and glial cells regulate these mitochondrial processes to facilitate axonal regeneration. Additionally, the review identifies existing challenges in SCI treatment and advocates for targeted interventions in mitochondrial dynamics as a promising therapeutic avenue, offering significant potential for advancing future research and treatment of SCI.https://doi.org/10.1186/s12967-025-06611-2Axonal mitochondriaAxonal regenerationDynamicsSpinal cord injury |
| spellingShingle | Kaixuan Wang Xi Chen Mengmin Liu Yunjuan Li Yihua Zhu Tiantong Zhou Weiwei Tao Yong Ma Yang Guo Lining Wang Yue Hu Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury Journal of Translational Medicine Axonal mitochondria Axonal regeneration Dynamics Spinal cord injury |
| title | Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| title_full | Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| title_fullStr | Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| title_full_unstemmed | Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| title_short | Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| title_sort | mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury |
| topic | Axonal mitochondria Axonal regeneration Dynamics Spinal cord injury |
| url | https://doi.org/10.1186/s12967-025-06611-2 |
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