Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women
Objective To explore the association between single nucleotide polymorphism (SNP) of Rab37 gene and the age at menarche(AAM). Methods A case-control study design was used to conduct an epidemiologic survey on 2 060 women in a community in Jurong City, Jiangsu Province, and their venous blood sam...
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Editorial Office of Journal of Army Medical University
2025-03-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | https://aammt.tmmu.edu.cn/html/202412046.html |
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| author | YUAN Meng YUAN Meng CAI Yang CAI Yang |
| author_facet | YUAN Meng YUAN Meng CAI Yang CAI Yang |
| author_sort | YUAN Meng |
| collection | DOAJ |
| description | Objective To explore the association between single nucleotide polymorphism (SNP) of Rab37 gene and the age at menarche(AAM). Methods A case-control study design was used to conduct an epidemiologic survey on 2 060 women in a community in Jurong City, Jiangsu Province, and their venous blood samples were collected. ASA chip was used to explore the Rab37 gene genotyping of blood sample DNA to obtain the genotyping results for Rab37 SNPs rs62084865, rs10512597, rs35489971, rs1037170, rs6501732, rs77822106, and rs3178300. Based on menarche time of <16 years old or ≥16 years old, the participants were divided into 2 groups. Linear and logistic regression analyses were used to explore the association between the SNP of Rab37 gene and the age at menarche based on dominant, recessive and allelic models. Results Among the 2 060 healthy women, 944 women had normal menstrual periods, while 1 116 women experienced delayed menarche. Linear regression analysis showed that the gene polymorphism of rs3178300 was negatively correlated with the age at menarche in females [recessive model: CC/CT+TT, β=-0.915, 95%CI(-1.692,-0.137), P=0.021; allelic model: T/C, β=-0.221, 95%CI(-0.410,-0.032), P=0.022]. Logistic regression analysis indicated that the gene polymorphism of rs3178300 was significantly associated with the risk of delayed menarche in females [recessive model: CC/CT+TT, OR=0.295, 95%CI (0.116,0.751), P=0.010; allelic model: T/C, OR=0.796, 95%CI(0.652,0.972), P=0.025]. The remaining 6 SNPs showed no significant association with age at menarche. Conclusion The rs3178300 polymorphism of Rab37 gene is significantly associated with delayed menarche in Chinese women.
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| format | Article |
| id | doaj-art-e6b16a8de3e544a29772898ee5dfe15c |
| institution | OA Journals |
| issn | 2097-0927 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj-art-e6b16a8de3e544a29772898ee5dfe15c2025-08-20T02:10:50ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272025-03-0147662362810.16016/j.2097-0927.202412046Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 womenYUAN Meng0YUAN Meng1CAI Yang2CAI Yang3Department of Epidemiology， Faculty of Military Preventive Medicine， Army Medical University （Third Military Medical University）， Chongqing Department of Disease Control and Prevention， General Hospital of Western Theater Command， Chengdu， SichuanDepartment of Epidemiology， Faculty of Military Preventive Medicine， Army Medical University （Third Military Medical University）， ChongqingCollege of Public Health， Southwest Medical University， Luzhou， Sichuan， ChinaObjective To explore the association between single nucleotide polymorphism (SNP) of Rab37 gene and the age at menarche(AAM). Methods A case-control study design was used to conduct an epidemiologic survey on 2 060 women in a community in Jurong City, Jiangsu Province, and their venous blood samples were collected. ASA chip was used to explore the Rab37 gene genotyping of blood sample DNA to obtain the genotyping results for Rab37 SNPs rs62084865, rs10512597, rs35489971, rs1037170, rs6501732, rs77822106, and rs3178300. Based on menarche time of <16 years old or ≥16 years old, the participants were divided into 2 groups. Linear and logistic regression analyses were used to explore the association between the SNP of Rab37 gene and the age at menarche based on dominant, recessive and allelic models. Results Among the 2 060 healthy women, 944 women had normal menstrual periods, while 1 116 women experienced delayed menarche. Linear regression analysis showed that the gene polymorphism of rs3178300 was negatively correlated with the age at menarche in females [recessive model: CC/CT+TT, β=-0.915, 95%CI(-1.692,-0.137), P=0.021; allelic model: T/C, β=-0.221, 95%CI(-0.410,-0.032), P=0.022]. Logistic regression analysis indicated that the gene polymorphism of rs3178300 was significantly associated with the risk of delayed menarche in females [recessive model: CC/CT+TT, OR=0.295, 95%CI (0.116,0.751), P=0.010; allelic model: T/C, OR=0.796, 95%CI(0.652,0.972), P=0.025]. The remaining 6 SNPs showed no significant association with age at menarche. Conclusion The rs3178300 polymorphism of Rab37 gene is significantly associated with delayed menarche in Chinese women. https://aammt.tmmu.edu.cn/html/202412046.htmlmenarchesingle nucleotide polymorphismcase-control studiesgenetic association studies |
| spellingShingle | YUAN Meng YUAN Meng CAI Yang CAI Yang Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women 陆军军医大学学报 menarche single nucleotide polymorphism case-control studies genetic association studies |
| title | Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women |
| title_full | Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women |
| title_fullStr | Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women |
| title_full_unstemmed | Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women |
| title_short | Association of Rab37 gene polymorphism and delayed menarche: a report of 2 060 women |
| title_sort | association of rab37 gene polymorphism and delayed menarche a report of 2 060 women |
| topic | menarche single nucleotide polymorphism case-control studies genetic association studies |
| url | https://aammt.tmmu.edu.cn/html/202412046.html |
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