An evaluation of distinct adeno-associated virus vector strategies for driving transgene expression in spinal inhibitory neurons of the rat

An evaluation of distinct adeno-associated virus vector strategies for driving transgene expression in spinal inhibitory neurons of the rat

The spinal cord dorsal horn (DH) is essential for processing and transmitting nociceptive information. Its neuronal subpopulations exhibit significant heterogeneity in morphology and intrinsic properties, forming complex circuits that remain only partially understood. Under physiological and patholo...

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Bibliographic Details
Main Authors: Laura Klinger, Anna S. M. Siegert, Raphael Holzinger, Lidia Trofimova, Sibel Ada, Ruth Drdla-Schutting
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Neuroscience
Subjects:
spinal cord
dorsal horn
inhibitory interneurons
nociception
adeno-associated virus vectors
intraparenchymal injection
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1558581/full
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