Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer
Abstract The reduction of skeletal muscle mass in catabolic conditions, such as cancer, is linked to adverse outcomes. Assessing muscle health provides valuable prognostic information, aiding therapeutic decisions to improve survival and quality of life. A-mode ultrasound is a portable, low-cost too...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-15995-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849234955747459072 |
|---|---|
| author | Rodrigo Albert Baracho Rüegg Jarson P. Costa-Pereira Amanda de Sousa Rebouças Agnes Denise de Lima Bezerra Nithaela Alves Bennemann Jadson Gomes Xavier Ana Paula Trussardi Fayh |
| author_facet | Rodrigo Albert Baracho Rüegg Jarson P. Costa-Pereira Amanda de Sousa Rebouças Agnes Denise de Lima Bezerra Nithaela Alves Bennemann Jadson Gomes Xavier Ana Paula Trussardi Fayh |
| author_sort | Rodrigo Albert Baracho Rüegg |
| collection | DOAJ |
| description | Abstract The reduction of skeletal muscle mass in catabolic conditions, such as cancer, is linked to adverse outcomes. Assessing muscle health provides valuable prognostic information, aiding therapeutic decisions to improve survival and quality of life. A-mode ultrasound is a portable, low-cost tool for body composition assessment, particularly useful in resource-limited settings. This study investigated the association between A-mode ultrasound -derived muscle thickness and adverse outcomes, including mortality, prolonged hospital stays, and readmissions. We included 358 patients (53.6% women, 50.4% with gastrointestinal tumors, 42.5% with TNM stage IV). Muscle thickness was measured at the biceps (BMT) and thigh (TMT). Only BMT independently predicted 30-day and 6-month mortality. Each millimeter increase in BMT reduced 30-day mortality risk by 9% (95% CI 0.85–0.96) and 6-month mortality risk by 6% (95% CI 0.91–0.98). TMT had no predictive value. BMT measured by A-mode ultrasound is a predictor of poor survival in cancer, highlighting its value as a bedside tool for early risk identification and timely interventions. Further research is needed to validate these findings and refine protocols for broader clinical use. |
| format | Article |
| id | doaj-art-e6ad5abc2fd3469e81ab4aee899e2d19 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e6ad5abc2fd3469e81ab4aee899e2d192025-08-20T04:02:56ZengNature PortfolioScientific Reports2045-23222025-08-011511810.1038/s41598-025-15995-6Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancerRodrigo Albert Baracho Rüegg0Jarson P. Costa-Pereira1Amanda de Sousa Rebouças2Agnes Denise de Lima Bezerra3Nithaela Alves Bennemann4Jadson Gomes Xavier5Ana Paula Trussardi Fayh6Postgraduate Program in Health Science, Federal University of Rio Grande do NortePostgraduate Program in Nutrition, Federal University of PernambucoPostgraduate Program in Health Science, Federal University of Rio Grande do NortePostgraduate Program in Health Science, Federal University of Rio Grande do NortePostgraduate Program in Health Science, Federal University of Rio Grande do NortePesqClin Lab, Brazilian Company of Hospital Services (EBSERH), Onofre Lopes University Hospital, Federal University of Rio Grande do NortePesqClin Lab, Brazilian Company of Hospital Services (EBSERH), Onofre Lopes University Hospital, Federal University of Rio Grande do NorteAbstract The reduction of skeletal muscle mass in catabolic conditions, such as cancer, is linked to adverse outcomes. Assessing muscle health provides valuable prognostic information, aiding therapeutic decisions to improve survival and quality of life. A-mode ultrasound is a portable, low-cost tool for body composition assessment, particularly useful in resource-limited settings. This study investigated the association between A-mode ultrasound -derived muscle thickness and adverse outcomes, including mortality, prolonged hospital stays, and readmissions. We included 358 patients (53.6% women, 50.4% with gastrointestinal tumors, 42.5% with TNM stage IV). Muscle thickness was measured at the biceps (BMT) and thigh (TMT). Only BMT independently predicted 30-day and 6-month mortality. Each millimeter increase in BMT reduced 30-day mortality risk by 9% (95% CI 0.85–0.96) and 6-month mortality risk by 6% (95% CI 0.91–0.98). TMT had no predictive value. BMT measured by A-mode ultrasound is a predictor of poor survival in cancer, highlighting its value as a bedside tool for early risk identification and timely interventions. Further research is needed to validate these findings and refine protocols for broader clinical use.https://doi.org/10.1038/s41598-025-15995-6Body compositionCancerMuscle healthSurvivalUltrasound |
| spellingShingle | Rodrigo Albert Baracho Rüegg Jarson P. Costa-Pereira Amanda de Sousa Rebouças Agnes Denise de Lima Bezerra Nithaela Alves Bennemann Jadson Gomes Xavier Ana Paula Trussardi Fayh Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer Scientific Reports Body composition Cancer Muscle health Survival Ultrasound |
| title | Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| title_full | Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| title_fullStr | Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| title_full_unstemmed | Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| title_short | Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| title_sort | muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer |
| topic | Body composition Cancer Muscle health Survival Ultrasound |
| url | https://doi.org/10.1038/s41598-025-15995-6 |
| work_keys_str_mv | AT rodrigoalbertbarachoruegg musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT jarsonpcostapereira musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT amandadesousareboucas musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT agnesdenisedelimabezerra musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT nithaelaalvesbennemann musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT jadsongomesxavier musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer AT anapaulatrussardifayh musclethicknessfromamplitudemodeultrasoundandclinicaloutcomesinpatientswithcancer |