Revealing the location and dynamics of a concealed binding site in the dopamine transporter

Revealing the location and dynamics of a concealed binding site in the dopamine transporter

Abstract The dopamine transporter (DAT) is linked to neuropsychiatric disorders including ADHD, Parkinson’s disease, and substance use disorders. Accordingly, DAT is the target of illicit drugs and clinically important medicines. However, the number and function of ligand binding sites in DAT is eni...

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Main Authors: Rong Zhu, Walter Sandtner, Thomas Stockner, Alexander Heilinger, Marion Holy, Oliver Kudlacek, Linda Wildling, Kusumika Saha, Anna Sophie Fröhlich, Michael Bindl, Paraskevi Tziortzouda, Anna Haider, Julia Gobl, Saanfor Hubert Suh, Jawad Akbar Khan, Julia Bicher, Nina Kastner, Andreas Ebner, Hermann J. Gruber, Michael Freissmuth, Amy Hauck Newman, Harald H. Sitte, Peter Hinterdorfer
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59511-w
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