Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Abstract Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion molecules. Parasites bindi...

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Bibliographic Details
Main Authors: Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander, Thomas Lavstsen
Format: Article
Language:English
Published: Springer Nature 2016-06-01
Series:EMBO Molecular Medicine
Subjects:
CIDR
EPCR
PfEMP1
severe childhood malaria
var
Online Access:https://doi.org/10.15252/emmm.201606188
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