Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients
Human T-cell leukemia virus type 1 (HTLV-1) is associated with an increased risk of tuberculosis (TB). This study aimed to evaluate the performance of the QuantiFERON-TB Gold (QFT) test for the diagnosis of <i>Mycobacterium tuberculosis</i> (MTB) infection in HTLV-1-infected individuals....
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/1999-4915/16/12/1873 |
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| author | Luana Leandro Gois Natália Barbosa Carvalho Fred Luciano Neves Santos Carlos Gustavo Regis-Silva Thainá Gonçalves Tolentino Figueiredo Bernardo Galvão-Castro Edgar Marcelino Carvalho Maria Fernanda Rios Grassi |
| author_facet | Luana Leandro Gois Natália Barbosa Carvalho Fred Luciano Neves Santos Carlos Gustavo Regis-Silva Thainá Gonçalves Tolentino Figueiredo Bernardo Galvão-Castro Edgar Marcelino Carvalho Maria Fernanda Rios Grassi |
| author_sort | Luana Leandro Gois |
| collection | DOAJ |
| description | Human T-cell leukemia virus type 1 (HTLV-1) is associated with an increased risk of tuberculosis (TB). This study aimed to evaluate the performance of the QuantiFERON-TB Gold (QFT) test for the diagnosis of <i>Mycobacterium tuberculosis</i> (MTB) infection in HTLV-1-infected individuals. HTLV-1-infected participants were divided into four groups: HTLV-1-infected individuals with a history of tuberculosis (HTLV/TB), individuals with positive HTLV and tuberculin skin tests (HTLV/TST+) or negative TST (HTLV/TST−), and HTLV-1-negative individuals with positive TST results (HN/TST+). We compared the diagnostic performance of the QFT assay with that of the TST as a reference and evaluated test sensitivity, specificity, accuracy, likelihood ratio, and diagnostic odds ratio. The results showed a higher frequency of positive TST results and induration diameter ≥10 mm in HTLV-1-infected individuals than in the controls. The QFT test was more frequently positive in the HTLV/TB group than in the other groups, while a combined analysis of HTLV/TB and HTLV/TST+ indicated a QFT sensitivity of 57.5%. No significant differences were found in the other diagnostic performance measures, as QFT test results were in agreement with TST results, particularly in TST-negative individuals. Given the low sensitivity of QFT for LTBI in individuals infected with HTLV-1, the TST may be preferable in regions where both infections are endemic. |
| format | Article |
| id | doaj-art-e6a3bcd2c3e94e64b27e0cf6d90536be |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Viruses |
| spelling | doaj-art-e6a3bcd2c3e94e64b27e0cf6d90536be2025-08-20T02:43:23ZengMDPI AGViruses1999-49152024-11-011612187310.3390/v16121873Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected PatientsLuana Leandro Gois0Natália Barbosa Carvalho1Fred Luciano Neves Santos2Carlos Gustavo Regis-Silva3Thainá Gonçalves Tolentino Figueiredo4Bernardo Galvão-Castro5Edgar Marcelino Carvalho6Maria Fernanda Rios Grassi7Departamento de Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador 40231-300, Bahia, BrazilServiço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador 40110-060, Bahia, BrazilLaboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, BrazilLaboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador 40290-000, Bahia, BrazilLaboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, BrazilServiço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador 40110-060, Bahia, BrazilLaboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz-BA), Salvador 40296-710, Bahia, BrazilHuman T-cell leukemia virus type 1 (HTLV-1) is associated with an increased risk of tuberculosis (TB). This study aimed to evaluate the performance of the QuantiFERON-TB Gold (QFT) test for the diagnosis of <i>Mycobacterium tuberculosis</i> (MTB) infection in HTLV-1-infected individuals. HTLV-1-infected participants were divided into four groups: HTLV-1-infected individuals with a history of tuberculosis (HTLV/TB), individuals with positive HTLV and tuberculin skin tests (HTLV/TST+) or negative TST (HTLV/TST−), and HTLV-1-negative individuals with positive TST results (HN/TST+). We compared the diagnostic performance of the QFT assay with that of the TST as a reference and evaluated test sensitivity, specificity, accuracy, likelihood ratio, and diagnostic odds ratio. The results showed a higher frequency of positive TST results and induration diameter ≥10 mm in HTLV-1-infected individuals than in the controls. The QFT test was more frequently positive in the HTLV/TB group than in the other groups, while a combined analysis of HTLV/TB and HTLV/TST+ indicated a QFT sensitivity of 57.5%. No significant differences were found in the other diagnostic performance measures, as QFT test results were in agreement with TST results, particularly in TST-negative individuals. Given the low sensitivity of QFT for LTBI in individuals infected with HTLV-1, the TST may be preferable in regions where both infections are endemic.https://www.mdpi.com/1999-4915/16/12/1873HTLV-1tuberculosistuberculin skin testQuantiFERON |
| spellingShingle | Luana Leandro Gois Natália Barbosa Carvalho Fred Luciano Neves Santos Carlos Gustavo Regis-Silva Thainá Gonçalves Tolentino Figueiredo Bernardo Galvão-Castro Edgar Marcelino Carvalho Maria Fernanda Rios Grassi Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients Viruses HTLV-1 tuberculosis tuberculin skin test QuantiFERON |
| title | Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients |
| title_full | Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients |
| title_fullStr | Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients |
| title_full_unstemmed | Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients |
| title_short | Evaluation of QuantiFERON-TB Gold for the Diagnosis of <i>Mycobacterium tuberculosis</i> Infection in HTLV-1-Infected Patients |
| title_sort | evaluation of quantiferon tb gold for the diagnosis of i mycobacterium tuberculosis i infection in htlv 1 infected patients |
| topic | HTLV-1 tuberculosis tuberculin skin test QuantiFERON |
| url | https://www.mdpi.com/1999-4915/16/12/1873 |
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