Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (<i>TRBC1</i>/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis of T-Cell Lymphoma

Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (<i>TRBC1</i>/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis of T-Cell Lymphoma

Background/Objectives: T-cell lymphomas are often histologically indistinguishable from benign T-cell infiltrates, and diagnosis typically relies on slow, complex, and expensive multiplexed PCR reactions, requiring significant training and experience to interpret them. We aimed to raise highly speci...

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Bibliographic Details
Main Authors: Elizabeth J. Soilleux, Daniel T. Rodgers, Jinlong J. Situ, Shelley C. Evans, Venkata N. Konda, Han-Chieh Yang, Jianxiong Pang, Isabella Gilbey Smith, Pete Rajesh, Maryam Salimi, Soo Weei Ng, Julia Jones, Jodi L. Miller, Rachel Etherington, Margaret Ashton-Key, Graham Ogg
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Diagnostics
Subjects:
lymphoma
monotypia
clonality
immunohistochemistry
diagnostic test
formalin-fixed paraffin-embedded tissue
Online Access:https://www.mdpi.com/2075-4418/14/22/2479
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