Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial
ABSTRACT Objectives In patients with lumbar spinal stenosis (LSS) undergoing unilateral biportal endoscopic unilateral laminotomy for bilateral decompression (UBE‐ULBD), damage to the epidural venous plexus often leads to bleeding, increasing the risk of surgical complications. Surgiflo Hemostatic M...
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Wiley
2025-05-01
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| Series: | Orthopaedic Surgery |
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| Online Access: | https://doi.org/10.1111/os.70009 |
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| author | Hao Yan Mei Gao Yu Zhang Huaibin Wang Yushan Zhu Tiangang Zhou Ruzhan Yao Weiqiang Liu Jesse Li‐Ling |
| author_facet | Hao Yan Mei Gao Yu Zhang Huaibin Wang Yushan Zhu Tiangang Zhou Ruzhan Yao Weiqiang Liu Jesse Li‐Ling |
| author_sort | Hao Yan |
| collection | DOAJ |
| description | ABSTRACT Objectives In patients with lumbar spinal stenosis (LSS) undergoing unilateral biportal endoscopic unilateral laminotomy for bilateral decompression (UBE‐ULBD), damage to the epidural venous plexus often leads to bleeding, increasing the risk of surgical complications. Surgiflo Hemostatic Matrix (SHM) is a gelatin extracted from porcine skin, used for intraoperative hemostasis. This study aims to evaluate the effectiveness and safety of using SHM during UBE‐ULBD surgery. Methods From October 2023 to July 2024, a total of 96 patients with LSS underwent UBE‐ULBD surgery. These 96 patients were randomly divided into two groups: the SHM group (48 patients, using flowable gelatin) and the non‐SHM group (48 patients, not using flowable gelatin). The primary outcomes included intraoperative blood loss, postoperative drainage volume, and the 3‐min hemostasis success rate. Secondary outcomes included symptomatic postoperative epidural hematoma (SPEH), surgical time, postoperative hospital stay, hospitalization costs, and complications. We used independent sample t‐tests to compare continuous data, and chi‐square tests or Fisher's exact tests to analyze categorical data. Results The intraoperative blood loss and postoperative drainage volume in the SHM group were significantly less than those in the non‐SHM group (p < 0.05), and the 3‐min hemostasis success rate in the SHM group was significantly higher than that in the non‐SHM group (p < 0.05). There were no statistically significant differences between the two groups regarding SPEH, postoperative hospital stay, hospitalization costs, and complications such as thrombosis formation and allergic reactions. However, the surgical time in the SHM group was significantly shorter than that in the non‐SHM group (p < 0.05). Conclusion When patients with LSS undergo UBE‐ULBD, the use of fluid gelatin can effectively reduce intraoperative and postoperative bleeding without introducing additional complications. |
| format | Article |
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| institution | OA Journals |
| issn | 1757-7853 1757-7861 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Orthopaedic Surgery |
| spelling | doaj-art-e6a19b3fc3e4439b8a9f1688269b75132025-08-20T02:10:57ZengWileyOrthopaedic Surgery1757-78531757-78612025-05-011751340134810.1111/os.70009Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled TrialHao Yan0Mei Gao1Yu Zhang2Huaibin Wang3Yushan Zhu4Tiangang Zhou5Ruzhan Yao6Weiqiang Liu7Jesse Li‐Ling8Department of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Hematology Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaDepartment of Spine Surgery Weifang People's Hospital, Shandong Second Medical University Weifang Shandong ChinaCenter of Medical Genetics, West China Second University Hospital, Sichuan University Chengdu Sichuan ChinaABSTRACT Objectives In patients with lumbar spinal stenosis (LSS) undergoing unilateral biportal endoscopic unilateral laminotomy for bilateral decompression (UBE‐ULBD), damage to the epidural venous plexus often leads to bleeding, increasing the risk of surgical complications. Surgiflo Hemostatic Matrix (SHM) is a gelatin extracted from porcine skin, used for intraoperative hemostasis. This study aims to evaluate the effectiveness and safety of using SHM during UBE‐ULBD surgery. Methods From October 2023 to July 2024, a total of 96 patients with LSS underwent UBE‐ULBD surgery. These 96 patients were randomly divided into two groups: the SHM group (48 patients, using flowable gelatin) and the non‐SHM group (48 patients, not using flowable gelatin). The primary outcomes included intraoperative blood loss, postoperative drainage volume, and the 3‐min hemostasis success rate. Secondary outcomes included symptomatic postoperative epidural hematoma (SPEH), surgical time, postoperative hospital stay, hospitalization costs, and complications. We used independent sample t‐tests to compare continuous data, and chi‐square tests or Fisher's exact tests to analyze categorical data. Results The intraoperative blood loss and postoperative drainage volume in the SHM group were significantly less than those in the non‐SHM group (p < 0.05), and the 3‐min hemostasis success rate in the SHM group was significantly higher than that in the non‐SHM group (p < 0.05). There were no statistically significant differences between the two groups regarding SPEH, postoperative hospital stay, hospitalization costs, and complications such as thrombosis formation and allergic reactions. However, the surgical time in the SHM group was significantly shorter than that in the non‐SHM group (p < 0.05). Conclusion When patients with LSS undergo UBE‐ULBD, the use of fluid gelatin can effectively reduce intraoperative and postoperative bleeding without introducing additional complications.https://doi.org/10.1111/os.70009fluid gelatinhemostasislumbar decompressionlumbar spinal stenosisunilateral biportal endoscopic |
| spellingShingle | Hao Yan Mei Gao Yu Zhang Huaibin Wang Yushan Zhu Tiangang Zhou Ruzhan Yao Weiqiang Liu Jesse Li‐Ling Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial Orthopaedic Surgery fluid gelatin hemostasis lumbar decompression lumbar spinal stenosis unilateral biportal endoscopic |
| title | Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial |
| title_full | Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial |
| title_fullStr | Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial |
| title_full_unstemmed | Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial |
| title_short | Use of Fluid Gelatin in Lumbar Spinal Stenosis Undergoing Unilateral Biportal Endoscopic: A Prospective, Randomized Controlled Trial |
| title_sort | use of fluid gelatin in lumbar spinal stenosis undergoing unilateral biportal endoscopic a prospective randomized controlled trial |
| topic | fluid gelatin hemostasis lumbar decompression lumbar spinal stenosis unilateral biportal endoscopic |
| url | https://doi.org/10.1111/os.70009 |
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