Disorganized thalamic subregional functional connectivity in bipolar I disorder
Abstract Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral cortex, limbic system, and other subcortical structures. In the present study, the potential involvement of the thalamus and subregi...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.771 |
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| author | Xipeng Long Xiuli Wang Yuan Cao Di Kong Baolin Wu Hongsheng Xie Ziru Zhao Neil Roberts Qiyong Gong Zhiyun Jia |
| author_facet | Xipeng Long Xiuli Wang Yuan Cao Di Kong Baolin Wu Hongsheng Xie Ziru Zhao Neil Roberts Qiyong Gong Zhiyun Jia |
| author_sort | Xipeng Long |
| collection | DOAJ |
| description | Abstract Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral cortex, limbic system, and other subcortical structures. In the present study, the potential involvement of the thalamus and subregions of the thalamus are explored in bipolar disorder (BD). In particular, functional and structural magnetic resonance imaging was performed on 73 adult patients with BD‐I and 78 healthy controls (HCs). Seed‐based thalamus and thalamic subregional functional connectivity (FC) were compared between the BD‐I patients and HCs. Compared to HCs, patients with BD‐I showed higher FC between the left thalamus and right lingual gyrus and altered FC between the dorsal thalamus and the default mode network and prefrontal regions, which may be correlated with mania symptomatology. In patients with BD‐I, the anterior subregions of the thalamus had higher FC than the posterior subregions. No significant difference in gray matter volume or local functional activity was found in the thalamus and thalamic subregions between BD‐I and HC. These findings provide evidence of disorganized thalamocortical FC in BD‐I, suggesting that the thalamus and its subregions may play important and specific roles in the neural circuitry of BD. |
| format | Article |
| id | doaj-art-e6a133fc6e8a43f49afdbb8626a68c30 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-e6a133fc6e8a43f49afdbb8626a68c302024-11-14T16:14:36ZengWileyMedComm2688-26632024-11-01511n/an/a10.1002/mco2.771Disorganized thalamic subregional functional connectivity in bipolar I disorderXipeng Long0Xiuli Wang1Yuan Cao2Di Kong3Baolin Wu4Hongsheng Xie5Ziru Zhao6Neil Roberts7Qiyong Gong8Zhiyun Jia9Department of Nuclear Medicine West China Hospital of Sichuan University Chengdu ChinaDepartment of Psychiatry the Fourth People's Hospital of Chengdu Chengdu ChinaDepartment of Nuclear Medicine West China Hospital of Sichuan University Chengdu ChinaDepartment of Psychiatry the Fourth People's Hospital of Chengdu Chengdu ChinaDepartment of Radiology and Huaxi MR Research Center (HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University Chengdu ChinaDepartment of Nuclear Medicine West China Hospital of Sichuan University Chengdu ChinaDepartment of Nuclear Medicine West China Hospital of Sichuan University Chengdu ChinaThe Queens Medical Research Institute (QMRI) School of Clinical Sciences University of Edinburgh Edinburgh UKDepartment of Radiology and Huaxi MR Research Center (HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University Chengdu ChinaDepartment of Nuclear Medicine West China Hospital of Sichuan University Chengdu ChinaAbstract Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral cortex, limbic system, and other subcortical structures. In the present study, the potential involvement of the thalamus and subregions of the thalamus are explored in bipolar disorder (BD). In particular, functional and structural magnetic resonance imaging was performed on 73 adult patients with BD‐I and 78 healthy controls (HCs). Seed‐based thalamus and thalamic subregional functional connectivity (FC) were compared between the BD‐I patients and HCs. Compared to HCs, patients with BD‐I showed higher FC between the left thalamus and right lingual gyrus and altered FC between the dorsal thalamus and the default mode network and prefrontal regions, which may be correlated with mania symptomatology. In patients with BD‐I, the anterior subregions of the thalamus had higher FC than the posterior subregions. No significant difference in gray matter volume or local functional activity was found in the thalamus and thalamic subregions between BD‐I and HC. These findings provide evidence of disorganized thalamocortical FC in BD‐I, suggesting that the thalamus and its subregions may play important and specific roles in the neural circuitry of BD.https://doi.org/10.1002/mco2.771bipolar disorderfunctional connectivitysubcorticalsubregionthalamus |
| spellingShingle | Xipeng Long Xiuli Wang Yuan Cao Di Kong Baolin Wu Hongsheng Xie Ziru Zhao Neil Roberts Qiyong Gong Zhiyun Jia Disorganized thalamic subregional functional connectivity in bipolar I disorder MedComm bipolar disorder functional connectivity subcortical subregion thalamus |
| title | Disorganized thalamic subregional functional connectivity in bipolar I disorder |
| title_full | Disorganized thalamic subregional functional connectivity in bipolar I disorder |
| title_fullStr | Disorganized thalamic subregional functional connectivity in bipolar I disorder |
| title_full_unstemmed | Disorganized thalamic subregional functional connectivity in bipolar I disorder |
| title_short | Disorganized thalamic subregional functional connectivity in bipolar I disorder |
| title_sort | disorganized thalamic subregional functional connectivity in bipolar i disorder |
| topic | bipolar disorder functional connectivity subcortical subregion thalamus |
| url | https://doi.org/10.1002/mco2.771 |
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