Age-related changes of vitamin C levels in aqueous humour
Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500063C.pdf |
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| author | Čanadananović Vladimir Latinović Slobodanka Barišić Sava Babić Nikola Jovanović Sandra |
| author_facet | Čanadananović Vladimir Latinović Slobodanka Barišić Sava Babić Nikola Jovanović Sandra |
| author_sort | Čanadananović Vladimir |
| collection | DOAJ |
| description | Background/Aim. Age-related cataract is a common disease among senior
population. Vitamin C is the most effective reducing hydrosoluble antioxidant
causing reduction in the levels of free radicals in crystaline lens. The aim
of this study was to evaluate the age-related change of vitamin C (L-ascorbic
acid) level in the aqueous humor of patients with senile cataract. Methods.
This prospective study included 74 patients, divided into 3 age groups, with
age-related cataract, underwent routine phaco cataract surgery with
intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at
the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic
acid) in aqueous humor were determined with high-performance liquid
chromatography (HPLC). Results. The average age of patients included in the
study was 65 ± 9.85 years (54-87 years). The level of vitamin C in aqueous
humor was 152.78 ± 7.0125 μg/mL in the group A (50-59 years), 134.15 ± 5.1569
μg/mL in the group B (60-69 years) and 106.51 ± 5.44 μg/mL in the group C
(over 70 years). Conclusion. The amount of vitamin C in aqueous humor of
patients with age-related cataract is decreasing with age. There was a
statistically significant change (p < 0.001) of vitamin C aqueous
concentration in the patients of different age. This decrease could play a
role in susceptibility to cataract formation in older population. |
| format | Article |
| id | doaj-art-e6a03d9ec86346568545ccfc5cab03e6 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-e6a03d9ec86346568545ccfc5cab03e62025-08-20T02:04:11ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202015-01-0172982382610.2298/VSP131212063C0042-84501500063CAge-related changes of vitamin C levels in aqueous humourČanadananović Vladimir0Latinović Slobodanka1Barišić Sava2Babić Nikola3Jovanović Sandra4Clinical Center of Vojvodina, Eye Clinic, Novi Sad + Faculty of Medicine, Novi SadEye Hospital “VIDAR-ORASIS Swiss”, Novi SadClinical Center of Vojvodina, Eye Clinic, Novi SadClinical Center of Vojvodina, Eye Clinic, Novi Sad + Faculty of Medicine, Novi SadClinical Center of Vojvodina, Eye Clinic, Novi Sad + Faculty of Medicine, Novi SadBackground/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C (L-ascorbic acid) level in the aqueous humor of patients with senile cataract. Methods. This prospective study included 74 patients, divided into 3 age groups, with age-related cataract, underwent routine phaco cataract surgery with intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic acid) in aqueous humor were determined with high-performance liquid chromatography (HPLC). Results. The average age of patients included in the study was 65 ± 9.85 years (54-87 years). The level of vitamin C in aqueous humor was 152.78 ± 7.0125 μg/mL in the group A (50-59 years), 134.15 ± 5.1569 μg/mL in the group B (60-69 years) and 106.51 ± 5.44 μg/mL in the group C (over 70 years). Conclusion. The amount of vitamin C in aqueous humor of patients with age-related cataract is decreasing with age. There was a statistically significant change (p < 0.001) of vitamin C aqueous concentration in the patients of different age. This decrease could play a role in susceptibility to cataract formation in older population.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500063C.pdfcataractaqueous humoragingascorbic acidchromatography |
| spellingShingle | Čanadananović Vladimir Latinović Slobodanka Barišić Sava Babić Nikola Jovanović Sandra Age-related changes of vitamin C levels in aqueous humour Vojnosanitetski Pregled cataract aqueous humor aging ascorbic acid chromatography |
| title | Age-related changes of vitamin C levels in aqueous humour |
| title_full | Age-related changes of vitamin C levels in aqueous humour |
| title_fullStr | Age-related changes of vitamin C levels in aqueous humour |
| title_full_unstemmed | Age-related changes of vitamin C levels in aqueous humour |
| title_short | Age-related changes of vitamin C levels in aqueous humour |
| title_sort | age related changes of vitamin c levels in aqueous humour |
| topic | cataract aqueous humor aging ascorbic acid chromatography |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500063C.pdf |
| work_keys_str_mv | AT canadananovicvladimir agerelatedchangesofvitaminclevelsinaqueoushumour AT latinovicslobodanka agerelatedchangesofvitaminclevelsinaqueoushumour AT barisicsava agerelatedchangesofvitaminclevelsinaqueoushumour AT babicnikola agerelatedchangesofvitaminclevelsinaqueoushumour AT jovanovicsandra agerelatedchangesofvitaminclevelsinaqueoushumour |