Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases
Background The underlying biological mechanisms linking blood pressure (BP) and cardiovascular diseases (CVD) are only partly understood. We aimed to identify metabolic signatures associated with systolic and diastolic BP and investigate their subsequent association with risk of CVD. Methods and Res...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.036573 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846142513889411072 |
|---|---|
| author | Maria Manou Christos Papagiannopoulos Christos V. Chalitsios Alexandros‐Georgios Asimakopoulos Georgios Markozannes Monica Bulló Konstantinos K. Tsilidis Christopher Papandreou Ioanna Tzoulaki |
| author_facet | Maria Manou Christos Papagiannopoulos Christos V. Chalitsios Alexandros‐Georgios Asimakopoulos Georgios Markozannes Monica Bulló Konstantinos K. Tsilidis Christopher Papandreou Ioanna Tzoulaki |
| author_sort | Maria Manou |
| collection | DOAJ |
| description | Background The underlying biological mechanisms linking blood pressure (BP) and cardiovascular diseases (CVD) are only partly understood. We aimed to identify metabolic signatures associated with systolic and diastolic BP and investigate their subsequent association with risk of CVD. Methods and Results The study included 201 742 UK Biobank participants with measurements on 249 metabolic biomarkers. A multistep adaptive elastic net penalized regression with 10‐fold cross‐validation was employed to identify metabolic signatures for systolic BP and diastolic BP. External validation was conducted on 848 participants from the EHS (Epirus Health Study). We further assessed the associations between BP metabolic signatures and incident composite CVD (N=6742), myocardial infarction (N=4192), and stroke (N=2757) in the UK Biobank, using multivariable Cox regression models. The metabolic signatures comprised 31 and 25 metabolites, robustly correlated with systolic BP and diastolic BP, respectively, in both the UK Biobank and the EHS. Following adjustments (including BP), the metabolic signature for systolic BP was positively associated with incident myocardial infarction (hazard ratio [HR], 1.11 [95% CI, 1.07–1.15]) and CVD (HR, 1.07 [95% CI, 1.04–1.10]). Similarly, the metabolic signature for diastolic BP was associated with a higher risk of myocardial infarction (HR, 1.16 [95% CI, 1.12–1.20]) and CVD (HR, 1.09 [95% CI, 1.05–1.12]). The associations between the signatures and stroke were not significant. The metabolic signatures partly mediated the total effect of the BP traits on the risk of myocardial infarction and CVD. Conclusions Our findings may enhance our understanding of the biological mechanisms through which BP affects CVD. |
| format | Article |
| id | doaj-art-e69be979f95c4812879da9f98a6500c7 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-e69be979f95c4812879da9f98a6500c72024-12-03T10:06:25ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-12-01132310.1161/JAHA.124.036573Metabolic Signatures of Blood Pressure and Risk of Cardiovascular DiseasesMaria Manou0Christos Papagiannopoulos1Christos V. Chalitsios2Alexandros‐Georgios Asimakopoulos3Georgios Markozannes4Monica Bulló5Konstantinos K. Tsilidis6Christopher Papandreou7Ioanna Tzoulaki8Department of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceDepartment of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceDepartment of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceDepartment of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceDepartment of Epidemiology and Biostatistics, School of Public Health Imperial College London London United KingdomNutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology Rovira i Virgili University (URV) Reus SpainDepartment of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceDepartment of Hygiene and Epidemiology, School of Medicine University of Ioannina GreeceBiomedical Research Foundation of the Academy of Athens Athens GreeceBackground The underlying biological mechanisms linking blood pressure (BP) and cardiovascular diseases (CVD) are only partly understood. We aimed to identify metabolic signatures associated with systolic and diastolic BP and investigate their subsequent association with risk of CVD. Methods and Results The study included 201 742 UK Biobank participants with measurements on 249 metabolic biomarkers. A multistep adaptive elastic net penalized regression with 10‐fold cross‐validation was employed to identify metabolic signatures for systolic BP and diastolic BP. External validation was conducted on 848 participants from the EHS (Epirus Health Study). We further assessed the associations between BP metabolic signatures and incident composite CVD (N=6742), myocardial infarction (N=4192), and stroke (N=2757) in the UK Biobank, using multivariable Cox regression models. The metabolic signatures comprised 31 and 25 metabolites, robustly correlated with systolic BP and diastolic BP, respectively, in both the UK Biobank and the EHS. Following adjustments (including BP), the metabolic signature for systolic BP was positively associated with incident myocardial infarction (hazard ratio [HR], 1.11 [95% CI, 1.07–1.15]) and CVD (HR, 1.07 [95% CI, 1.04–1.10]). Similarly, the metabolic signature for diastolic BP was associated with a higher risk of myocardial infarction (HR, 1.16 [95% CI, 1.12–1.20]) and CVD (HR, 1.09 [95% CI, 1.05–1.12]). The associations between the signatures and stroke were not significant. The metabolic signatures partly mediated the total effect of the BP traits on the risk of myocardial infarction and CVD. Conclusions Our findings may enhance our understanding of the biological mechanisms through which BP affects CVD.https://www.ahajournals.org/doi/10.1161/JAHA.124.036573blood pressurecardiovascular diseasemetabolic signaturesmetabolomicsNMRUK Biobank |
| spellingShingle | Maria Manou Christos Papagiannopoulos Christos V. Chalitsios Alexandros‐Georgios Asimakopoulos Georgios Markozannes Monica Bulló Konstantinos K. Tsilidis Christopher Papandreou Ioanna Tzoulaki Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease blood pressure cardiovascular disease metabolic signatures metabolomics NMR UK Biobank |
| title | Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases |
| title_full | Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases |
| title_fullStr | Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases |
| title_full_unstemmed | Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases |
| title_short | Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases |
| title_sort | metabolic signatures of blood pressure and risk of cardiovascular diseases |
| topic | blood pressure cardiovascular disease metabolic signatures metabolomics NMR UK Biobank |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.036573 |
| work_keys_str_mv | AT mariamanou metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT christospapagiannopoulos metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT christosvchalitsios metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT alexandrosgeorgiosasimakopoulos metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT georgiosmarkozannes metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT monicabullo metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT konstantinosktsilidis metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT christopherpapandreou metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases AT ioannatzoulaki metabolicsignaturesofbloodpressureandriskofcardiovasculardiseases |