Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions
This review aims to highlight the challenges encountered in managing Polycythemia Vera in resource-limited settings and to suggest a cost-effective strategy for timely diagnosis and treatment. Presentation to healthcare facilities at an advanced stage due to lack of awareness and limited access to...
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| Format: | Article |
| Language: | English |
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Liaquat National Hospital and Medical College
2025-07-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/5bb8f639-936c-4ae3-acc0-71d0fafb4177.pdf |
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| _version_ | 1849245709649313792 |
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| author | Rabab Jafry Safia Mehmood Khan Uzma Zaidi Gul Sufaida Samina Naz Mukry |
| author_facet | Rabab Jafry Safia Mehmood Khan Uzma Zaidi Gul Sufaida Samina Naz Mukry |
| author_sort | Rabab Jafry |
| collection | DOAJ |
| description | This review aims to highlight the challenges encountered in managing Polycythemia Vera in resource-limited settings and to suggest
a cost-effective strategy for timely diagnosis and treatment. Presentation to healthcare facilities at an advanced stage due to lack of
awareness and limited access to medical care, delay in the diagnosis due to inadequate healthcare infrastructure, unavailability of
molecular testing in the majority of centers, and suboptimal disease management, primarily due to lack of physician awareness and
expertise in handling this condition are the key factors contributing to the higher rates of complications, including thrombotic events
and disease progression, ultimately leading to poorer patient prognoses in Pakistani population. This review describes and evaluates
a cost-effective diagnostic and treatment approach to Polycythemia Vera to reduce the morbidity and mortality of the disorder in
Pakistan. A tailored investigation plan comprising of JAK2 mutation and serum erythropoietin levels and minimal cytoreductive
therapy combined with phlebotomy and anti-platelet agent can be implemented to achieve optimal management of the disease in a
resource-constrained country |
| format | Article |
| id | doaj-art-e69a74af2a5944f0ada51fbe296b7ea1 |
| institution | Kabale University |
| issn | 2707-3521 2708-9134 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj-art-e69a74af2a5944f0ada51fbe296b7ea12025-08-20T03:58:44ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342025-07-017326827410.37184/lnjpc.2707-3521.7.55Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible SolutionsRabab Jafry0Safia Mehmood Khan1Uzma Zaidi2Gul Sufaida3Samina Naz Mukry4Agha Khan University Hospital, Karachi, PakistanNational Institute of Blood Disease and Bone Marrow Transplant, Karachi, PakistanNational Institute of Blood Disease and Bone Marrow Transplant, Karachi, PakistanNational Institute of Blood Disease and Bone Marrow Transplant, Karachi, PakistanNational Institute of Blood Disease and Bone Marrow Transplant, Karachi, PakistanThis review aims to highlight the challenges encountered in managing Polycythemia Vera in resource-limited settings and to suggest a cost-effective strategy for timely diagnosis and treatment. Presentation to healthcare facilities at an advanced stage due to lack of awareness and limited access to medical care, delay in the diagnosis due to inadequate healthcare infrastructure, unavailability of molecular testing in the majority of centers, and suboptimal disease management, primarily due to lack of physician awareness and expertise in handling this condition are the key factors contributing to the higher rates of complications, including thrombotic events and disease progression, ultimately leading to poorer patient prognoses in Pakistani population. This review describes and evaluates a cost-effective diagnostic and treatment approach to Polycythemia Vera to reduce the morbidity and mortality of the disorder in Pakistan. A tailored investigation plan comprising of JAK2 mutation and serum erythropoietin levels and minimal cytoreductive therapy combined with phlebotomy and anti-platelet agent can be implemented to achieve optimal management of the disease in a resource-constrained countryhttps://journals.lnh.edu.pk/lnjpc/pdf/5bb8f639-936c-4ae3-acc0-71d0fafb4177.pdfpolycythemia verapakistancytoreduction therapycost effectivejak2 mutation |
| spellingShingle | Rabab Jafry Safia Mehmood Khan Uzma Zaidi Gul Sufaida Samina Naz Mukry Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions Liaquat National Journal of Primary Care polycythemia vera pakistan cytoreduction therapy cost effective jak2 mutation |
| title | Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions |
| title_full | Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions |
| title_fullStr | Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions |
| title_full_unstemmed | Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions |
| title_short | Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions |
| title_sort | diagnosis and treatment of polycythemia vera in pakistan barriers and possible solutions |
| topic | polycythemia vera pakistan cytoreduction therapy cost effective jak2 mutation |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/5bb8f639-936c-4ae3-acc0-71d0fafb4177.pdf |
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