SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS
The objective of the present investigation was to synthesize novel quinoline derivatives for antibacterial activity. Five compounds SK1-5 were synthesized and these compounds were tested yield (%), solubility, retention factor (Rf) and melting point (°C). The compounds were evaluated for antibacteri...
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Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2025-03-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
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| Online Access: | https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202501&vol=1&aid=5710 |
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| author | SEEMA KHAN NARENDRA K. SINGH SHANKAR SINGH AVINASH K. KONDALKAR |
| author_facet | SEEMA KHAN NARENDRA K. SINGH SHANKAR SINGH AVINASH K. KONDALKAR |
| author_sort | SEEMA KHAN |
| collection | DOAJ |
| description | The objective of the present investigation was to synthesize novel quinoline derivatives for antibacterial activity. Five compounds SK1-5 were synthesized and these compounds were tested yield (%), solubility, retention factor (Rf) and melting point (°C). The compounds were evaluated for antibacterial activity using zone of inhibition method at four different concentrations. The products were insoluble in water, methanol and DMSO while they were soluble in chloroform and were obtained in 67 - 76 % yield. The antibacterial action against both gram-positive and gram-negative bacteria was exhibited by the compounds. The compounds were found to be possessing better inhibitory action against the gram-negative bacteria in comparison to gram positive bacteria. The zone of inhibition exhibited by SK3 was highest among all compound and it was equally effective in both gram-negative and positive bacteria. |
| format | Article |
| id | doaj-art-e6992f445f754029b5c874715565d198 |
| institution | OA Journals |
| issn | 1582-540X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Alma Mater Publishing House "Vasile Alecsandri" University of Bacau |
| record_format | Article |
| series | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| spelling | doaj-art-e6992f445f754029b5c874715565d1982025-08-20T01:54:12ZengAlma Mater Publishing House "Vasile Alecsandri" University of BacauScientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry1582-540X2025-03-01251015022https://doi.org/10.29081/ChIBA.2025.600SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTSSEEMA KHAN0NARENDRA K. SINGH1SHANKAR SINGH2AVINASH K. KONDALKAR 3Sun Institute of Pharmaceutical Education and Research, Lahar, Department of Pharmaceutical Chemistry, Lahar-Bhatpura Road, Madhya Pradesh-477445, IndiaSun Institute of Pharmaceutical Education and Research, Lahar, Department of Pharmaceutical Chemistry, Lahar-Bhatpura Road, Madhya Pradesh-477445, IndiaSun Institute of Pharmaceutical Education and Research, Lahar, Department of Pharmaceutical Chemistry, Lahar-Bhatpura Road, Madhya Pradesh-477445, IndiaSun Institute of Pharmaceutical Education and Research, Lahar, Department of Pharmaceutical Chemistry, Lahar-Bhatpura Road, Madhya Pradesh-477445, IndiaThe objective of the present investigation was to synthesize novel quinoline derivatives for antibacterial activity. Five compounds SK1-5 were synthesized and these compounds were tested yield (%), solubility, retention factor (Rf) and melting point (°C). The compounds were evaluated for antibacterial activity using zone of inhibition method at four different concentrations. The products were insoluble in water, methanol and DMSO while they were soluble in chloroform and were obtained in 67 - 76 % yield. The antibacterial action against both gram-positive and gram-negative bacteria was exhibited by the compounds. The compounds were found to be possessing better inhibitory action against the gram-negative bacteria in comparison to gram positive bacteria. The zone of inhibition exhibited by SK3 was highest among all compound and it was equally effective in both gram-negative and positive bacteria.https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202501&vol=1&aid=5710conrad-limpachepichlorohydrinethyl acetoacetatedisc diffusionzone of inhibition |
| spellingShingle | SEEMA KHAN NARENDRA K. SINGH SHANKAR SINGH AVINASH K. KONDALKAR SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry conrad-limpach epichlorohydrin ethyl acetoacetate disc diffusion zone of inhibition |
| title | SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS |
| title_full | SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS |
| title_fullStr | SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS |
| title_full_unstemmed | SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS |
| title_short | SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL QUINOLINE MOLECULES AS ANTIBACTERIAL AGENTS |
| title_sort | synthesis characterization and evaluation of novel quinoline molecules as antibacterial agents |
| topic | conrad-limpach epichlorohydrin ethyl acetoacetate disc diffusion zone of inhibition |
| url | https://pubs.ub.ro/?pg=revues&rev=cscc6&num=202501&vol=1&aid=5710 |
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