Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
Reactive oxygen species (ROS) are a class of bioactive molecules that are the by-products of many cellular functions. These molecules are present in normal cells at homeostatic levels but have been studied extensively in cancer due to their dysregulation resulting in pro- and anti-tumorigenic enviro...
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| Format: | Article |
| Language: | English |
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Istanbul University Press
2023-12-01
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| Series: | European Journal of Biology |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/93364EBD84A04BDAAE7EC8BD70898930 |
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| author | Christoffer B Lambring Liling Chen Claire Nelson Alyssa Stevens Wynashia Bratcher Riyaz Basha |
| author_facet | Christoffer B Lambring Liling Chen Claire Nelson Alyssa Stevens Wynashia Bratcher Riyaz Basha |
| author_sort | Christoffer B Lambring |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are a class of bioactive molecules that are the by-products of many cellular functions. These molecules are present in normal cells at homeostatic levels but have been studied extensively in cancer due to their dysregulation resulting in pro- and anti-tumorigenic environments. Completely understanding the paradoxical nature of ROS in cancer is imperative to fully realize its modulation as cancer therapy. Studies into ROS have shown far-reaching effects in cancer, including how ROS levels regulate signaling, response to treatment, drug resistance, etc. Many drugs were studied with the hopes of regulating the ROS levels in cancer; however, patient response varied. Plant-derived medications offered new avenues of drug treatment over the last few decades, and the phytochemical Curcumin gained ground as an interesting cancer therapeutic. Curcumin is an active phenolic compound used in traditional medicine around the world. Although it suffers from a poor pharmacokinetic profile, Curcumin exerts anti-tumorigenic, as well as ROS-modulating activities. Analogs and derivatives of Curcumin are under development to improve upon its anti-cancer properties and enhance its bioavailability, currently a major limitation of its usage. This review highlights ROS function in cancer treatment focused on ROS, including Curcumin and its analogs. |
| format | Article |
| id | doaj-art-e69491b1792448c49e400a618f82507e |
| institution | OA Journals |
| issn | 2618-6144 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | European Journal of Biology |
| spelling | doaj-art-e69491b1792448c49e400a618f82507e2025-08-20T02:10:39ZengIstanbul University PressEuropean Journal of Biology2618-61442023-12-0182231732510.26650/EurJBiol.2023.1348427123456Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against CancerChristoffer B Lambring0https://orcid.org/0009-0003-2921-5021Liling Chen1https://orcid.org/0009-0006-0191-1887Claire Nelson2https://orcid.org/0009-0008-9256-4634Alyssa Stevens3https://orcid.org/0009-0005-6799-0090Wynashia Bratcher4https://orcid.org/0000-0002-4071-0993Riyaz Basha5University of North Texas, Texas, USAUniversity of North Texas, Texas, USAMissouri Southern State University, Missouri, USAMissouri Southern State University, Missouri, USALivingstone College, Salisbury, North-CarolinaUniversity of North Texas, Texas, USAReactive oxygen species (ROS) are a class of bioactive molecules that are the by-products of many cellular functions. These molecules are present in normal cells at homeostatic levels but have been studied extensively in cancer due to their dysregulation resulting in pro- and anti-tumorigenic environments. Completely understanding the paradoxical nature of ROS in cancer is imperative to fully realize its modulation as cancer therapy. Studies into ROS have shown far-reaching effects in cancer, including how ROS levels regulate signaling, response to treatment, drug resistance, etc. Many drugs were studied with the hopes of regulating the ROS levels in cancer; however, patient response varied. Plant-derived medications offered new avenues of drug treatment over the last few decades, and the phytochemical Curcumin gained ground as an interesting cancer therapeutic. Curcumin is an active phenolic compound used in traditional medicine around the world. Although it suffers from a poor pharmacokinetic profile, Curcumin exerts anti-tumorigenic, as well as ROS-modulating activities. Analogs and derivatives of Curcumin are under development to improve upon its anti-cancer properties and enhance its bioavailability, currently a major limitation of its usage. This review highlights ROS function in cancer treatment focused on ROS, including Curcumin and its analogs.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/93364EBD84A04BDAAE7EC8BD70898930oxidative stresscurcumincurcumin analogscancer therapyros-modulating drugs |
| spellingShingle | Christoffer B Lambring Liling Chen Claire Nelson Alyssa Stevens Wynashia Bratcher Riyaz Basha Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer European Journal of Biology oxidative stress curcumin curcumin analogs cancer therapy ros-modulating drugs |
| title | Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer |
| title_full | Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer |
| title_fullStr | Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer |
| title_full_unstemmed | Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer |
| title_short | Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer |
| title_sort | oxidative stress and cancer harnessing the therapeutic potential of curcumin and analogues against cancer |
| topic | oxidative stress curcumin curcumin analogs cancer therapy ros-modulating drugs |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/93364EBD84A04BDAAE7EC8BD70898930 |
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