Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo
Background. Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autore...
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| Language: | English |
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Wiley
2021-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/5524566 |
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| author | Thai Van Thanh Le Huy Ngoc Phan Tran Ngoc Dang Le Duy Pham |
| author_facet | Thai Van Thanh Le Huy Ngoc Phan Tran Ngoc Dang Le Duy Pham |
| author_sort | Thai Van Thanh Le |
| collection | DOAJ |
| description | Background. Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. IL-17A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus. Objective. We evaluated the relationship between serum levels of IL-17A and the clinicopathological characteristics of Vietnamese vitiligo patients. Methods. In this cross-sectional study, we analyzed data from 52 nonsegmental vitiligo patients and 50 age- and sex-matched healthy individuals. Serum levels of IL-17A were measured using an enzyme-linked immunosorbent assay. We evaluated the correlation between IL-17A levels and clinical characteristics including leukotrichia, disease duration, vitiligo activity, and body surface area involvement. Results. Patients with progressive vitiligo had significantly higher IL-17A levels than patients with stable vitiligo (P = 0.014) or healthy individuals (P = 0.002). In addition, serum IL-17A levels were higher in vitiligo patients with leukotrichia than in patients without it (P = 0.04). Furthermore, serum IL-17A levels were negatively correlated with age (r = −0.39, P = 0.004) and age of onset (r = −0.33, P = 0.016) in vitiligo patients. Conclusions. Higher serum levels of IL-17A in patients with progressive vitiligo and leukotrichia suggest a potential role of IL-17A in melanocyte destruction in the epidermis and the follicular matrix. |
| format | Article |
| id | doaj-art-e690c2b6de4a460fb3781593b1cbd414 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-e690c2b6de4a460fb3781593b1cbd4142025-02-03T01:01:24ZengWileyDermatology Research and Practice1687-61051687-61132021-01-01202110.1155/2021/55245665524566Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial VitiligoThai Van Thanh Le0Huy Ngoc Phan1Tran Ngoc Dang2Le Duy Pham3Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamHo Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City, VietnamFaculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamBackground. Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. IL-17A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus. Objective. We evaluated the relationship between serum levels of IL-17A and the clinicopathological characteristics of Vietnamese vitiligo patients. Methods. In this cross-sectional study, we analyzed data from 52 nonsegmental vitiligo patients and 50 age- and sex-matched healthy individuals. Serum levels of IL-17A were measured using an enzyme-linked immunosorbent assay. We evaluated the correlation between IL-17A levels and clinical characteristics including leukotrichia, disease duration, vitiligo activity, and body surface area involvement. Results. Patients with progressive vitiligo had significantly higher IL-17A levels than patients with stable vitiligo (P = 0.014) or healthy individuals (P = 0.002). In addition, serum IL-17A levels were higher in vitiligo patients with leukotrichia than in patients without it (P = 0.04). Furthermore, serum IL-17A levels were negatively correlated with age (r = −0.39, P = 0.004) and age of onset (r = −0.33, P = 0.016) in vitiligo patients. Conclusions. Higher serum levels of IL-17A in patients with progressive vitiligo and leukotrichia suggest a potential role of IL-17A in melanocyte destruction in the epidermis and the follicular matrix.http://dx.doi.org/10.1155/2021/5524566 |
| spellingShingle | Thai Van Thanh Le Huy Ngoc Phan Tran Ngoc Dang Le Duy Pham Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo Dermatology Research and Practice |
| title | Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo |
| title_full | Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo |
| title_fullStr | Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo |
| title_full_unstemmed | Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo |
| title_short | Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo |
| title_sort | increased circulatory interleukin 17a levels in patients with progressive and leukotrichial vitiligo |
| url | http://dx.doi.org/10.1155/2021/5524566 |
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