The mechanism of acetyl-CoA synthase through the lens of a nickel model system

Abstract Given the urgent need to develop new methods of CO2/CO utilization, understanding the mechanism of acetyl-CoA synthase (ACS)—a primordial nickel-containing enzyme that converts these gases into a source of cellular energy—is crucial; however, conflicting hypotheses and a dearth of well-char...

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Bibliographic Details
Main Authors: Shounak Nath, Leonel Griego, Liviu M. Mirica
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60163-z
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