Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration
Abstract We evaluated the efficacy of switching to intravitreal injection of faricimab (IVF) in patients with aflibercept-refractory neovascular age-related macular degeneration (nAMD) over 2 years of follow-up. We retrospectively reviewed 47 consecutive eyes of 45 Japanese patients with nAMD who sw...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-15194-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226314540646400 |
|---|---|
| author | Masaaki Saito Kimihiro Imaizumi |
| author_facet | Masaaki Saito Kimihiro Imaizumi |
| author_sort | Masaaki Saito |
| collection | DOAJ |
| description | Abstract We evaluated the efficacy of switching to intravitreal injection of faricimab (IVF) in patients with aflibercept-refractory neovascular age-related macular degeneration (nAMD) over 2 years of follow-up. We retrospectively reviewed 47 consecutive eyes of 45 Japanese patients with nAMD who switched from aflibercept to faricimab. Thirty-one eyes of 30 Japanese patients were included in this study. The mean visual acuity (BCVA) at month 24 was stable relative to the baseline. The mean central retinal thickness and subfoveal choroidal thinning significantly decreased at 24 months (P < 0.0001, P < 0.0001, respectively). At 24 months, 22 eyes (70.0%) achieved a dry macula and had improved VA levels with an improvement of 0.80 lines, which was significantly different from the remaining 9 eyes (P < 0.01). The mean interval of IVF was 11.8 weeks, which was significantly longer than that of aflibercept (10.0 weeks) at baseline (p = 0.014). Progression of macular atrophy or newly developing macular atrophy was seen in 3 eyes (9.7%), showing decline of 1.0 line, no other complications were seen. These results indicate that switching to IVF stabilized VA, significantly improved the anatomical changes and the achievement of a dry macula was significantly associated with the visual outcome, in patients with aflibercept-refractory nAMD over a 24-month period. |
| format | Article |
| id | doaj-art-e68cf6f523884aec8033a0ae3c8a8ceb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e68cf6f523884aec8033a0ae3c8a8ceb2025-08-24T11:28:26ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-15194-3Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degenerationMasaaki Saito0Kimihiro Imaizumi1Department of Regional Vision Reconstruction, Fukushima Medical UniversityIwaki City Medical CenterAbstract We evaluated the efficacy of switching to intravitreal injection of faricimab (IVF) in patients with aflibercept-refractory neovascular age-related macular degeneration (nAMD) over 2 years of follow-up. We retrospectively reviewed 47 consecutive eyes of 45 Japanese patients with nAMD who switched from aflibercept to faricimab. Thirty-one eyes of 30 Japanese patients were included in this study. The mean visual acuity (BCVA) at month 24 was stable relative to the baseline. The mean central retinal thickness and subfoveal choroidal thinning significantly decreased at 24 months (P < 0.0001, P < 0.0001, respectively). At 24 months, 22 eyes (70.0%) achieved a dry macula and had improved VA levels with an improvement of 0.80 lines, which was significantly different from the remaining 9 eyes (P < 0.01). The mean interval of IVF was 11.8 weeks, which was significantly longer than that of aflibercept (10.0 weeks) at baseline (p = 0.014). Progression of macular atrophy or newly developing macular atrophy was seen in 3 eyes (9.7%), showing decline of 1.0 line, no other complications were seen. These results indicate that switching to IVF stabilized VA, significantly improved the anatomical changes and the achievement of a dry macula was significantly associated with the visual outcome, in patients with aflibercept-refractory nAMD over a 24-month period.https://doi.org/10.1038/s41598-025-15194-3Neovascular age-related macular degeneration Macular neovascularizationFaricimabAfliberceptRefractoryOptical coherence tomography angiography |
| spellingShingle | Masaaki Saito Kimihiro Imaizumi Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration Scientific Reports Neovascular age-related macular degeneration Macular neovascularization Faricimab Aflibercept Refractory Optical coherence tomography angiography |
| title | Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration |
| title_full | Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration |
| title_fullStr | Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration |
| title_full_unstemmed | Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration |
| title_short | Two-year results of switching to intravitreal administration of faricimab in patients with aflibercept-refractory neovascular age-related macular degeneration |
| title_sort | two year results of switching to intravitreal administration of faricimab in patients with aflibercept refractory neovascular age related macular degeneration |
| topic | Neovascular age-related macular degeneration Macular neovascularization Faricimab Aflibercept Refractory Optical coherence tomography angiography |
| url | https://doi.org/10.1038/s41598-025-15194-3 |
| work_keys_str_mv | AT masaakisaito twoyearresultsofswitchingtointravitrealadministrationoffaricimabinpatientswithafliberceptrefractoryneovascularagerelatedmaculardegeneration AT kimihiroimaizumi twoyearresultsofswitchingtointravitrealadministrationoffaricimabinpatientswithafliberceptrefractoryneovascularagerelatedmaculardegeneration |