Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors
The Masquelet technique, also known as the induced membrane technique, is a surgical technique for repairing large bone defects based on the use of a membrane generated by a foreign body reaction for bone grafting. This technique is not only simple to perform, with few complications and quick recove...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Chinese Journal of Traumatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1008127524000543 |
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| author | Jiang-Hong Wu Quan-Wei Bao Shao-Kang Wang Pan-Yu Zhou Shuo-Gui Xu |
| author_facet | Jiang-Hong Wu Quan-Wei Bao Shao-Kang Wang Pan-Yu Zhou Shuo-Gui Xu |
| author_sort | Jiang-Hong Wu |
| collection | DOAJ |
| description | The Masquelet technique, also known as the induced membrane technique, is a surgical technique for repairing large bone defects based on the use of a membrane generated by a foreign body reaction for bone grafting. This technique is not only simple to perform, with few complications and quick recovery, but also has excellent clinical results. To better understand the mechanisms by which this technique promotes bone defect repair and the factors that require special attention in practice, we examined and summarized the relevant research advances in this technique by searching, reading, and analysing the literature. Literature show that the Masquelet technique may promote the repair of bone defects through the physical septum and molecular barrier, vascular network, enrichment of mesenchymal stem cells, and high expression of bone-related growth factors, and the repair process is affected by the properties of spacers, the timing of bone graft, mechanical environment, intramembrane filling materials, artificial membrane, and pharmaceutical/biological agents/physical stimulation. |
| format | Article |
| id | doaj-art-e68b52159e274fd0b8f6ab37367d0fc1 |
| institution | Kabale University |
| issn | 1008-1275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chinese Journal of Traumatology |
| spelling | doaj-art-e68b52159e274fd0b8f6ab37367d0fc12025-08-20T03:53:56ZengElsevierChinese Journal of Traumatology1008-12752025-05-0128315716310.1016/j.cjtee.2024.04.003Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factorsJiang-Hong Wu0Quan-Wei Bao1Shao-Kang Wang2Pan-Yu Zhou3Shuo-Gui Xu4Department of Emergency, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaTrauma Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, ChinaDepartment of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Corresponding author.The Masquelet technique, also known as the induced membrane technique, is a surgical technique for repairing large bone defects based on the use of a membrane generated by a foreign body reaction for bone grafting. This technique is not only simple to perform, with few complications and quick recovery, but also has excellent clinical results. To better understand the mechanisms by which this technique promotes bone defect repair and the factors that require special attention in practice, we examined and summarized the relevant research advances in this technique by searching, reading, and analysing the literature. Literature show that the Masquelet technique may promote the repair of bone defects through the physical septum and molecular barrier, vascular network, enrichment of mesenchymal stem cells, and high expression of bone-related growth factors, and the repair process is affected by the properties of spacers, the timing of bone graft, mechanical environment, intramembrane filling materials, artificial membrane, and pharmaceutical/biological agents/physical stimulation.http://www.sciencedirect.com/science/article/pii/S1008127524000543Bone defectsMasquelet techniqueInduced membrane techniqueBone repairBiological chamber |
| spellingShingle | Jiang-Hong Wu Quan-Wei Bao Shao-Kang Wang Pan-Yu Zhou Shuo-Gui Xu Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors Chinese Journal of Traumatology Bone defects Masquelet technique Induced membrane technique Bone repair Biological chamber |
| title | Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors |
| title_full | Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors |
| title_fullStr | Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors |
| title_full_unstemmed | Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors |
| title_short | Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors |
| title_sort | mechanisms of the masquelet technique to promote bone defect repair and its influencing factors |
| topic | Bone defects Masquelet technique Induced membrane technique Bone repair Biological chamber |
| url | http://www.sciencedirect.com/science/article/pii/S1008127524000543 |
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