Benefits of fecal microbiota transplantation: A comprehensive review
A growing body of literatures showed the interaction of dysbiotic gut with a wide range of disorders, and the clinical use of fecal microbiota transplantation (FMT) shifted from infectious disease to non-communicable disorders. Despite the promising therapeutic benefits of FMT, the exact mechanisms...
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The Journal of Infection in Developing Countries
2020-10-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/12780 |
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| author | Muluneh Ademe |
| author_facet | Muluneh Ademe |
| author_sort | Muluneh Ademe |
| collection | DOAJ |
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A growing body of literatures showed the interaction of dysbiotic gut with a wide range of disorders, and the clinical use of fecal microbiota transplantation (FMT) shifted from infectious disease to non-communicable disorders. Despite the promising therapeutic benefits of FMT, the exact mechanisms through which fecal recipients benefit from the fecal intervention are not well understood. However, owing to the advantages of having a healthy gut microbiome, possible mechanisms of actions of FMT has been described. On the one hand, through direct ecological competition, FMT may potentially stimulate decolonization of pathogenic microorganisms and increase host resistance to pathogens. Moreover, following dysbiosis, abnormal microbial colonization of the gastrointestinal tract may also cause excessive or dysregulated immune response, resulting in chronic inflammation and the development of mucosal lesions. In this regard, repopulating gut microbiome through FMT helps to restore immune function and reduce host damage. On the other hand, FMT helps to restore essential metabolites used for host metabolism, including short-chain fatty acids (SCFA), antimicrobial peptides (AMP), bacteriocins and bile acids. Therefore, in this review, the existing evidences regarding the mechanisms of action, current opportunities and challenges of FMT will be described.
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| format | Article |
| id | doaj-art-e689d34463be47b9913918da30b0f2e2 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-e689d34463be47b9913918da30b0f2e22025-08-20T02:27:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802020-10-01141010.3855/jidc.12780Benefits of fecal microbiota transplantation: A comprehensive reviewMuluneh Ademe0Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia A growing body of literatures showed the interaction of dysbiotic gut with a wide range of disorders, and the clinical use of fecal microbiota transplantation (FMT) shifted from infectious disease to non-communicable disorders. Despite the promising therapeutic benefits of FMT, the exact mechanisms through which fecal recipients benefit from the fecal intervention are not well understood. However, owing to the advantages of having a healthy gut microbiome, possible mechanisms of actions of FMT has been described. On the one hand, through direct ecological competition, FMT may potentially stimulate decolonization of pathogenic microorganisms and increase host resistance to pathogens. Moreover, following dysbiosis, abnormal microbial colonization of the gastrointestinal tract may also cause excessive or dysregulated immune response, resulting in chronic inflammation and the development of mucosal lesions. In this regard, repopulating gut microbiome through FMT helps to restore immune function and reduce host damage. On the other hand, FMT helps to restore essential metabolites used for host metabolism, including short-chain fatty acids (SCFA), antimicrobial peptides (AMP), bacteriocins and bile acids. Therefore, in this review, the existing evidences regarding the mechanisms of action, current opportunities and challenges of FMT will be described. https://jidc.org/index.php/journal/article/view/12780Fecal transplantationColonization resistanceMechanismsStool bankChallenges |
| spellingShingle | Muluneh Ademe Benefits of fecal microbiota transplantation: A comprehensive review Journal of Infection in Developing Countries Fecal transplantation Colonization resistance Mechanisms Stool bank Challenges |
| title | Benefits of fecal microbiota transplantation: A comprehensive review |
| title_full | Benefits of fecal microbiota transplantation: A comprehensive review |
| title_fullStr | Benefits of fecal microbiota transplantation: A comprehensive review |
| title_full_unstemmed | Benefits of fecal microbiota transplantation: A comprehensive review |
| title_short | Benefits of fecal microbiota transplantation: A comprehensive review |
| title_sort | benefits of fecal microbiota transplantation a comprehensive review |
| topic | Fecal transplantation Colonization resistance Mechanisms Stool bank Challenges |
| url | https://jidc.org/index.php/journal/article/view/12780 |
| work_keys_str_mv | AT mulunehademe benefitsoffecalmicrobiotatransplantationacomprehensivereview |