Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

Summary: DNA double-strand breaks (DSBs) are highly detrimental to cells, as improper repair can result in inheritable genetic rearrangements or cell death. The role of RNA:DNA hybrids (RDHs) in DSB repair remains poorly understood, but their transient accumulation and subsequent resolution are cruc...

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Bibliographic Details
Main Authors: Aditya Mojumdar, Courtney Granger, Martine Lunke, Ellis Evans, Jennifer A. Cobb
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014968
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