Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries
Abstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge in cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, the inherent bioinert nature...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-03-01
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| Series: | Collagen and Leather |
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| Online Access: | https://doi.org/10.1186/s42825-025-00192-y |
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| author | Yan Liu Can Cheng Jiaqi Xing Zhaoxi Deng Xu Peng |
| author_facet | Yan Liu Can Cheng Jiaqi Xing Zhaoxi Deng Xu Peng |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | Abstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge in cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, the inherent bioinert nature leads to high failure rates in < 6 mm diameter applications due to thrombotic complications and mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as a biologically strategic alternative, preserving crucial vascular basement membrane components and biomechanical cues through collagen/elastin retention. The present review systematically elaborates the research advancements, critical determinants, and practical challenges in utilizing dECM for tiny-diameter artificial vessels (inner diameter < 3 mm), while proposing three forward-looking solutions to address clinical translation barriers: (1) matrix optimization strategies through diameter-specific compliance matching and elastin reconstitution; (2) sterilization and preservation protocols preserving structural integrity with controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. The proposed methodologies establish innovative avenues for the engineering and clinical transplantation of tiny-diameter artificial vessels. Graphical abstract |
| format | Article |
| id | doaj-art-e689586591f740cda97a932b72d9bf7d |
| institution | Kabale University |
| issn | 2097-1419 2731-6998 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Collagen and Leather |
| spelling | doaj-art-e689586591f740cda97a932b72d9bf7d2025-08-20T03:40:45ZengSpringerOpenCollagen and Leather2097-14192731-69982025-03-017112510.1186/s42825-025-00192-yRecent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteriesYan Liu0Can Cheng1Jiaqi Xing2Zhaoxi Deng3Xu Peng4West China School of Basic Medical Sciences and Forensic Medicine, Experimental and Research Animal Institute, Sichuan UniversityCollege of Polymer Science and Engineering, Sichuan UniversityMax Planck Institute for Polymer ResearchWest China School of Basic Medical Sciences and Forensic Medicine, Experimental and Research Animal Institute, Sichuan UniversityWest China School of Basic Medical Sciences and Forensic Medicine, Experimental and Research Animal Institute, Sichuan UniversityAbstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge in cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, the inherent bioinert nature leads to high failure rates in < 6 mm diameter applications due to thrombotic complications and mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as a biologically strategic alternative, preserving crucial vascular basement membrane components and biomechanical cues through collagen/elastin retention. The present review systematically elaborates the research advancements, critical determinants, and practical challenges in utilizing dECM for tiny-diameter artificial vessels (inner diameter < 3 mm), while proposing three forward-looking solutions to address clinical translation barriers: (1) matrix optimization strategies through diameter-specific compliance matching and elastin reconstitution; (2) sterilization and preservation protocols preserving structural integrity with controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. The proposed methodologies establish innovative avenues for the engineering and clinical transplantation of tiny-diameter artificial vessels. Graphical abstracthttps://doi.org/10.1186/s42825-025-00192-yDecellularized matrixCollagenTiny artificial arteryElastinImmunomodulationSterilization |
| spellingShingle | Yan Liu Can Cheng Jiaqi Xing Zhaoxi Deng Xu Peng Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries Collagen and Leather Decellularized matrix Collagen Tiny artificial artery Elastin Immunomodulation Sterilization |
| title | Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries |
| title_full | Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries |
| title_fullStr | Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries |
| title_full_unstemmed | Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries |
| title_short | Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries |
| title_sort | recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny diameter artificial arteries |
| topic | Decellularized matrix Collagen Tiny artificial artery Elastin Immunomodulation Sterilization |
| url | https://doi.org/10.1186/s42825-025-00192-y |
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