IL-36 signaling as a drug target in Crohn’s disease patients with IL36RN mutations

IL-36 signaling as a drug target in Crohn’s disease patients with IL36RN mutations

Abstract The IL-36 signaling pathway has recently been identified as a key regulator of intestinal homeostasis and inflammation. However, the role of mutations in the IL-36R signaling pathway in the pathogenesis of inflammatory bowel disease remains unclear. We here identified four Crohn’s disease p...

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Main Authors: Julia Hecker, Christina Plattner, Camila A Cancino, Britt-Sabina Löscher, Judith Saurenbach, Marilena Letizia, Dietmar Rieder, TRR241 IBDome Consortium, Inka Freise, Kristina Koop, Clemens Neufert, Désirée Kunkel, Zainab Al Khatim, Lars-Arne Schaafs, Anja Schütz, Christoph Becker, Raja Atreya, Zlatko Trajanoski, Andre Franke, Elena Sonnenberg, Ahmed N Hegazy, Britta Siegmund, Carl Weidinger
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:EMBO Molecular Medicine
Subjects:
IL-36 Signaling
Crohn’s Disease
Personalized Therapy
Genetics
Online Access:https://doi.org/10.1038/s44321-025-00245-z
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