SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress inflammation during Listeria monocytogenes infection

SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress inflammation during Listeria monocytogenes infection

ABSTRACT Listeria monocytogenes, a foodborne pathogen, has the ability to invade intestinal mucosal cells, undergo intracellular proliferation, activate host immune responses, and induce diseases such as colitis. We have demonstrated that sentrin-specific protease 1 (SENP1) functions as a protective...

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Main Authors: Yan Xiong, Yongliang Du, Feng Lin, Beibei Fu, Dong Guo, Zhou Sha, Rong Tian, Rui Yao, Lulu Wang, Zixuan Cong, Bohao Li, Xiaoyuan Lin, Haibo Wu
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
SENP1-SIRT3 axis
SUMO
glycolysis
PKM2
Listeria monocytogenes
Online Access:https://journals.asm.org/doi/10.1128/mbio.02524-24
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