Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patients
Vasoactive prostanoids may be involved in persistent pulmonary hypertension (PPH) in infants with a congenital diaphragmatic hernia (CDH). We hypothesized that increased levels of prostanoids in bronchoalveolar lavage (BAL) fluid would predict clinical outcome. We measured the concentrations of 6-ke...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791712 |
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| author | H. Ijsselstijn F. J. Zijlstra J. C. De Jongste D. Tibboel |
| author_facet | H. Ijsselstijn F. J. Zijlstra J. C. De Jongste D. Tibboel |
| author_sort | H. Ijsselstijn |
| collection | DOAJ |
| description | Vasoactive prostanoids may be involved in persistent pulmonary hypertension (PPH) in infants with a congenital diaphragmatic hernia (CDH). We hypothesized that increased levels of prostanoids in bronchoalveolar lavage (BAL) fluid would predict clinical outcome. We measured the concentrations of 6-keto-prostaglandin F1α (6-keto-PGF1α), thromboxane B2 (TxB2), protein, albumin, total cell count, and elastase-α1-proteinase-inhibitor complex in BAL fluid of 18 CDH patients and of 13 control subjects without PPH. We found different concentrations of prostanoids in BAL fluid of CDH patients with PPH: infants with a poor prognosis had either high levels of both 6-keto-PGF1α and TxB2 compared to controls, or high levels of
6-keto-PGF1α only. TxB2 levels showed a large variability in all CDH patients irrespective of outcome. We conclude that prostanoid levels in BAL fluid do not predict clinical outcome in CDH patients. |
| format | Article |
| id | doaj-art-e685ab9116d544bfa9cdb34e651cebc5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e685ab9116d544bfa9cdb34e651cebc52025-02-03T01:24:31ZengWileyMediators of Inflammation0962-93511466-18611997-01-016321722410.1080/09629359791712Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patientsH. Ijsselstijn0F. J. Zijlstra1J. C. De Jongste2D. Tibboel3Department of Paediatric Surgery, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Rotterdam, The NetherlandsDepartment of Pharmacology, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Rotterdam, The NetherlandsDepartment of Paediatrics, Division of Respiratory Medicine, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Rotterdam, The NetherlandsDepartment of Paediatric Surgery, Erasmus University Rotterdam and University Hospital/Sophia Children's Hospital, Rotterdam, The NetherlandsVasoactive prostanoids may be involved in persistent pulmonary hypertension (PPH) in infants with a congenital diaphragmatic hernia (CDH). We hypothesized that increased levels of prostanoids in bronchoalveolar lavage (BAL) fluid would predict clinical outcome. We measured the concentrations of 6-keto-prostaglandin F1α (6-keto-PGF1α), thromboxane B2 (TxB2), protein, albumin, total cell count, and elastase-α1-proteinase-inhibitor complex in BAL fluid of 18 CDH patients and of 13 control subjects without PPH. We found different concentrations of prostanoids in BAL fluid of CDH patients with PPH: infants with a poor prognosis had either high levels of both 6-keto-PGF1α and TxB2 compared to controls, or high levels of 6-keto-PGF1α only. TxB2 levels showed a large variability in all CDH patients irrespective of outcome. We conclude that prostanoid levels in BAL fluid do not predict clinical outcome in CDH patients.http://dx.doi.org/10.1080/09629359791712 |
| spellingShingle | H. Ijsselstijn F. J. Zijlstra J. C. De Jongste D. Tibboel Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patients Mediators of Inflammation |
| title | Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital
diaphragmatic hernia patients |
| title_full | Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital
diaphragmatic hernia patients |
| title_fullStr | Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital
diaphragmatic hernia patients |
| title_full_unstemmed | Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital
diaphragmatic hernia patients |
| title_short | Prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital
diaphragmatic hernia patients |
| title_sort | prostanoids in bronchoalveolar lavage fluid do not predict outcome in congenital diaphragmatic hernia patients |
| url | http://dx.doi.org/10.1080/09629359791712 |
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