Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic
Both Type 2 Diabetes Mellitus (T2DM) and depression are leading causes of disability despite T2DM being largely preventable and depression being among the most treatable mental health conditions. Diabetes and depression have a bidirectional association, with each condition worsening the development...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Psychoactives |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2813-1851/4/2/13 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849432385895006208 |
|---|---|
| author | Bradley M. Brooks Ashley M. Nettles Brandon M. Brooks |
| author_facet | Bradley M. Brooks Ashley M. Nettles Brandon M. Brooks |
| author_sort | Bradley M. Brooks |
| collection | DOAJ |
| description | Both Type 2 Diabetes Mellitus (T2DM) and depression are leading causes of disability despite T2DM being largely preventable and depression being among the most treatable mental health conditions. Diabetes and depression have a bidirectional association, with each condition worsening the development and progression of the other. Depression in patients with diabetes is linked with poor glycemic control, reduced treatment adherence, and increased risk of diabetes complications. On the other hand, chronic hyperglycemia, systemic inflammation, insulin resistance, and neuroendocrine dysregulation are involved in the pathophysiology of depression. Antidepressants are often used to treat depression in diabetic patients, but their metabolic impact is still a matter of concern. While some antidepressants like fluoxetine and escitalopram increase insulin sensitivity and improve glycemic parameters, others such as especially tricyclic antidepressants (TCAs) and certain selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of diabetes, weight gain, and poor cardiometabolic outcomes. Considering such complexities, the prescribing of antidepressants must be done carefully. This review underscores the need for evidence-based and patient-centric pharmacological management. Further, the inclusion of psychiatry in multidisciplinary diabetes care teams has the potential to maximize both metabolic and psychological health benefits, as well as reduce the complications of T2DM. |
| format | Article |
| id | doaj-art-e68009d86301498c89d1fa39e6bc67b9 |
| institution | Kabale University |
| issn | 2813-1851 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Psychoactives |
| spelling | doaj-art-e68009d86301498c89d1fa39e6bc67b92025-08-20T03:27:22ZengMDPI AGPsychoactives2813-18512025-05-01421310.3390/psychoactives4020013Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes PandemicBradley M. Brooks0Ashley M. Nettles1Brandon M. Brooks2USA Department of Psychiatry, University of South Alabama, Mobile, AL 36609, USASurgical Service, Columbia VA Health Care System, Columbia, SC 29209, USASurgical Service, Columbia VA Health Care System, Columbia, SC 29209, USABoth Type 2 Diabetes Mellitus (T2DM) and depression are leading causes of disability despite T2DM being largely preventable and depression being among the most treatable mental health conditions. Diabetes and depression have a bidirectional association, with each condition worsening the development and progression of the other. Depression in patients with diabetes is linked with poor glycemic control, reduced treatment adherence, and increased risk of diabetes complications. On the other hand, chronic hyperglycemia, systemic inflammation, insulin resistance, and neuroendocrine dysregulation are involved in the pathophysiology of depression. Antidepressants are often used to treat depression in diabetic patients, but their metabolic impact is still a matter of concern. While some antidepressants like fluoxetine and escitalopram increase insulin sensitivity and improve glycemic parameters, others such as especially tricyclic antidepressants (TCAs) and certain selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of diabetes, weight gain, and poor cardiometabolic outcomes. Considering such complexities, the prescribing of antidepressants must be done carefully. This review underscores the need for evidence-based and patient-centric pharmacological management. Further, the inclusion of psychiatry in multidisciplinary diabetes care teams has the potential to maximize both metabolic and psychological health benefits, as well as reduce the complications of T2DM.https://www.mdpi.com/2813-1851/4/2/13antidepressantsdiabetes mellitusdepressioninsulin resistancepsychiatryselective serotonin reuptake inhibitors |
| spellingShingle | Bradley M. Brooks Ashley M. Nettles Brandon M. Brooks Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic Psychoactives antidepressants diabetes mellitus depression insulin resistance psychiatry selective serotonin reuptake inhibitors |
| title | Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic |
| title_full | Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic |
| title_fullStr | Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic |
| title_full_unstemmed | Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic |
| title_short | Diabetes Psychiatry: The Missing Piece of the Puzzle to Prevent Complications of the Diabetes Pandemic |
| title_sort | diabetes psychiatry the missing piece of the puzzle to prevent complications of the diabetes pandemic |
| topic | antidepressants diabetes mellitus depression insulin resistance psychiatry selective serotonin reuptake inhibitors |
| url | https://www.mdpi.com/2813-1851/4/2/13 |
| work_keys_str_mv | AT bradleymbrooks diabetespsychiatrythemissingpieceofthepuzzletopreventcomplicationsofthediabetespandemic AT ashleymnettles diabetespsychiatrythemissingpieceofthepuzzletopreventcomplicationsofthediabetespandemic AT brandonmbrooks diabetespsychiatrythemissingpieceofthepuzzletopreventcomplicationsofthediabetespandemic |