Emerging Strategies to Overcome Chemoresistance: Structural Insights and Therapeutic Targeting of Multidrug Resistance-Linked ATP-Binding Cassette Transporters

Emerging Strategies to Overcome Chemoresistance: Structural Insights and Therapeutic Targeting of Multidrug Resistance-Linked ATP-Binding Cassette Transporters

The ATP-binding cassette (ABC) transporter superfamily, one of the largest membrane protein families, plays a crucial role in multidrug resistance (MDR) in cancer by mediating the efflux of various chemotherapeutic agents, thereby lowering their intracellular concentrations and diminishing therapeut...

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Bibliographic Details
Main Authors:	Raghavendra Sashi Krishna Nagampalli, Gangadhar P. Vadla, Eswar Kumar Nadendla
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	International Journal of Translational Medicine
Subjects:	ABC transporters multidrug resistance (MDR) ABC transporter inhibitors cancer therapeutics drug efflux mechanism
Online Access:	https://www.mdpi.com/2673-8937/5/1/6
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