HLA class II-restricted T cell epitopes in public neoantigens of ESR1 and PIK3CA in breast cancer

HLA class II-restricted T cell epitopes in public neoantigens of ESR1 and PIK3CA in breast cancer

Abstract Background The high occurrence of treatment resistance in patients with hormone receptor-positive (HR +) breast cancer is a global health concern. Thus, effective immunotherapy must be developed. The public neoantigens, estrogen receptor 1 (ESR1) and phosphatidylinositol-4,5-bisphosphate 3-...

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Bibliographic Details
Main Authors: Yukari Ando, Hiroko Miyadera, Hiroko Bando, Sachie Hashimoto, Emiko Noguchi, Hisato Hara
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Breast neoplasms
Cancer vaccines
Epitopes
T-Lymphocyte
Histocompatibility antigen class II
Neoantigen
Online Access:https://doi.org/10.1186/s12885-025-13992-6
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