Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model
Abstract Background Sweet potato (Ipomoea batatas (L.) Lam.) is a member of the family Convolvulaceae. Much research has highlighted its variable biological actions in the treatment of many disorders. Our study focused on the quantitative analysis of two Egyptian sweet potato cultivars (Abees and A1...
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| Format: | Article |
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SpringerOpen
2025-01-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-025-00762-1 |
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| author | Rehab M. Elgabry Ghada A. Fawzy Khaled M. Meselhy Nehal M. Ramadan Nihal Farid Younes Areej M. Al-Taweel Shagufta Perveen Mohamed S. Sedeek |
| author_facet | Rehab M. Elgabry Ghada A. Fawzy Khaled M. Meselhy Nehal M. Ramadan Nihal Farid Younes Areej M. Al-Taweel Shagufta Perveen Mohamed S. Sedeek |
| author_sort | Rehab M. Elgabry |
| collection | DOAJ |
| description | Abstract Background Sweet potato (Ipomoea batatas (L.) Lam.) is a member of the family Convolvulaceae. Much research has highlighted its variable biological actions in the treatment of many disorders. Our study focused on the quantitative analysis of two Egyptian sweet potato cultivars (Abees and A195). First, we applied proximate analysis, measured total phenolic, and flavonoid contents, performing an HPLC standardization of their ethanolic extracts using chlorogenic acid standard. Furthermore, the two cultivars were formulated as topical creams (3% w/w and 5% w/w) and evaluated for their anti-skin aging activity in a d-galactose-induced skin aging mouse model. Results revealed that both cultivars have high nutritional importance. Results Abees exhibited higher total phenolic and flavonoid contents than A195, while A195 contained a higher concentration of chlorogenic acid. Both cultivars showed a concentration-dependent anti-skin aging activity, with 5% Abees cream demonstrating the lowest visual skin-aging score, the highest activity of catalase (CAT) and superoxide dismutase (SOD), and the lowest concentration of malondialdehyde (MDA). Restoration of skin thickness and collagen content was observed in the 5% Abees group, while both Abees and A195 caused a noticeable concentration-dependent decrease in the skin SMAD7 expression. Decreased SMAD7 has been correlated to upregulating the TGF-β/SMAD3-induced collagen production in aged skin. Conclusion This study elaborates the nutritional importance, phenolic and flavonoid content and anti-skin aging activity of Abees and A195 roots and we recommend further preclinical and clinical investigations of sweet potato. |
| format | Article |
| id | doaj-art-e67c5549b6b84505ae9973a2693b53c1 |
| institution | Kabale University |
| issn | 2314-7253 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj-art-e67c5549b6b84505ae9973a2693b53c12025-01-12T12:11:09ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532025-01-0111111510.1186/s43094-025-00762-1Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging modelRehab M. Elgabry0Ghada A. Fawzy1Khaled M. Meselhy2Nehal M. Ramadan3Nihal Farid Younes4Areej M. Al-Taweel5Shagufta Perveen6Mohamed S. Sedeek7Department of Pharmacognosy, Faculty of Pharmacy, Cairo UniversityDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo UniversityDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo UniversityClinical Pharmacology Department, Faculty of Medicine, Mansoura UniversityDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El Aini St.,11562Department of Pharmacognosy, College of Pharmacy, King Saud UniversityDepartment of Bacteriology, University of Wisconsin-MadisonDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo UniversityAbstract Background Sweet potato (Ipomoea batatas (L.) Lam.) is a member of the family Convolvulaceae. Much research has highlighted its variable biological actions in the treatment of many disorders. Our study focused on the quantitative analysis of two Egyptian sweet potato cultivars (Abees and A195). First, we applied proximate analysis, measured total phenolic, and flavonoid contents, performing an HPLC standardization of their ethanolic extracts using chlorogenic acid standard. Furthermore, the two cultivars were formulated as topical creams (3% w/w and 5% w/w) and evaluated for their anti-skin aging activity in a d-galactose-induced skin aging mouse model. Results revealed that both cultivars have high nutritional importance. Results Abees exhibited higher total phenolic and flavonoid contents than A195, while A195 contained a higher concentration of chlorogenic acid. Both cultivars showed a concentration-dependent anti-skin aging activity, with 5% Abees cream demonstrating the lowest visual skin-aging score, the highest activity of catalase (CAT) and superoxide dismutase (SOD), and the lowest concentration of malondialdehyde (MDA). Restoration of skin thickness and collagen content was observed in the 5% Abees group, while both Abees and A195 caused a noticeable concentration-dependent decrease in the skin SMAD7 expression. Decreased SMAD7 has been correlated to upregulating the TGF-β/SMAD3-induced collagen production in aged skin. Conclusion This study elaborates the nutritional importance, phenolic and flavonoid content and anti-skin aging activity of Abees and A195 roots and we recommend further preclinical and clinical investigations of sweet potato.https://doi.org/10.1186/s43094-025-00762-1Nutritional value of AbeesSkin aging markersTGF-β and SMAD signalingChlorogenic acid contentHPLC analysis |
| spellingShingle | Rehab M. Elgabry Ghada A. Fawzy Khaled M. Meselhy Nehal M. Ramadan Nihal Farid Younes Areej M. Al-Taweel Shagufta Perveen Mohamed S. Sedeek Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model Future Journal of Pharmaceutical Sciences Nutritional value of Abees Skin aging markers TGF-β and SMAD signaling Chlorogenic acid content HPLC analysis |
| title | Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model |
| title_full | Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model |
| title_fullStr | Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model |
| title_full_unstemmed | Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model |
| title_short | Phytochemical analysis and anti-aging efficacy of two Egyptian sweet potato cultivars in a d-galactose-induced skin aging model |
| title_sort | phytochemical analysis and anti aging efficacy of two egyptian sweet potato cultivars in a d galactose induced skin aging model |
| topic | Nutritional value of Abees Skin aging markers TGF-β and SMAD signaling Chlorogenic acid content HPLC analysis |
| url | https://doi.org/10.1186/s43094-025-00762-1 |
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