Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases
Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 1...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/174062 |
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| author | Lindner Ewald Langner-Wegscheider Beate Sarny Stephanie Renner Wilfried El-Shabrawi Yosuf |
| author_facet | Lindner Ewald Langner-Wegscheider Beate Sarny Stephanie Renner Wilfried El-Shabrawi Yosuf |
| author_sort | Lindner Ewald |
| collection | DOAJ |
| description | Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 132 controls, and 65 HLAB27 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p=0.04; OR: 1.46; CI: 1.02–2.11). Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p>0.05). Conclusion. These findings further deepen our understanding of the commonality between multiple sclerosis and intermediate uveitis. Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets. |
| format | Article |
| id | doaj-art-e67c3fbdacb146cd9b6f4c69d24dee43 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e67c3fbdacb146cd9b6f4c69d24dee432025-02-03T01:24:31ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/174062174062Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune DiseasesLindner Ewald0Langner-Wegscheider Beate1Sarny Stephanie2Renner Wilfried3El-Shabrawi Yosuf4Department of Ophthalmology, Medical University Graz, Auenbruggerplatz 4, 8036 Graz, AustriaDepartment of Ophthalmology, Medical University Graz, Auenbruggerplatz 4, 8036 Graz, AustriaDepartment of Ophthalmology, General Hospital Klagenfurt, St. Veiter Strasse 47, 9020 Klagenfurt, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, AustriaDepartment of Ophthalmology, Medical University Graz, Auenbruggerplatz 4, 8036 Graz, AustriaPurpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. Methods. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 132 controls, and 65 HLAB27 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p=0.04; OR: 1.46; CI: 1.02–2.11). Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p>0.05). Conclusion. These findings further deepen our understanding of the commonality between multiple sclerosis and intermediate uveitis. Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.http://dx.doi.org/10.1155/2015/174062 |
| spellingShingle | Lindner Ewald Langner-Wegscheider Beate Sarny Stephanie Renner Wilfried El-Shabrawi Yosuf Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases Journal of Immunology Research |
| title | Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases |
| title_full | Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases |
| title_fullStr | Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases |
| title_full_unstemmed | Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases |
| title_short | Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases |
| title_sort | analysis of a functional il 6 gene polymorphism in hlab27 associated and intermediate uveitis gives new insight in disease pathogenesis and commonality with other autoimmune diseases |
| url | http://dx.doi.org/10.1155/2015/174062 |
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