The role of USP36 in ribosome biogenesis and other pathophysiological processes
Ubiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis. As a member of deubiquitination enzyme USP family, USP36 maintains the stability of substrate proteins by mediating their deubiquit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1650908/full |
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| _version_ | 1849233707288756224 |
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| author | Linxin Shao Mengqi Guo Qianrui Kou Ya Guo Xin Li Fang Li |
| author_facet | Linxin Shao Mengqi Guo Qianrui Kou Ya Guo Xin Li Fang Li |
| author_sort | Linxin Shao |
| collection | DOAJ |
| description | Ubiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis. As a member of deubiquitination enzyme USP family, USP36 maintains the stability of substrate proteins by mediating their deubiquitination, thereby playing a significant role in various pathophysiological processes. Here we focus on discussing how USP36 participates in regulating ribosome biosynthesis and responds to ribotoxic stress response. Furthermore, this review has elucidated the role of USP36 in regulating DNA replication stress, hypoxia adaptation, oxidative stress, and selective autophagy, as well as the related molecular mechanisms. This review is very helpful for understanding the role of USP36 in pathophysiological process and exploring the possibility of USP36 as a target for disease treatment. |
| format | Article |
| id | doaj-art-e67b600442d34fb7808c56676f6659bf |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-e67b600442d34fb7808c56676f6659bf2025-08-20T04:14:17ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-08-011210.3389/fmolb.2025.16509081650908The role of USP36 in ribosome biogenesis and other pathophysiological processesLinxin ShaoMengqi GuoQianrui KouYa GuoXin LiFang LiUbiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis. As a member of deubiquitination enzyme USP family, USP36 maintains the stability of substrate proteins by mediating their deubiquitination, thereby playing a significant role in various pathophysiological processes. Here we focus on discussing how USP36 participates in regulating ribosome biosynthesis and responds to ribotoxic stress response. Furthermore, this review has elucidated the role of USP36 in regulating DNA replication stress, hypoxia adaptation, oxidative stress, and selective autophagy, as well as the related molecular mechanisms. This review is very helpful for understanding the role of USP36 in pathophysiological process and exploring the possibility of USP36 as a target for disease treatment.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1650908/fullubiquitin-specific peptidase 36ribosome biosynthesisDNA replication stresshypoxia adaptationoxidative stressselective autophagy |
| spellingShingle | Linxin Shao Mengqi Guo Qianrui Kou Ya Guo Xin Li Fang Li The role of USP36 in ribosome biogenesis and other pathophysiological processes Frontiers in Molecular Biosciences ubiquitin-specific peptidase 36 ribosome biosynthesis DNA replication stress hypoxia adaptation oxidative stress selective autophagy |
| title | The role of USP36 in ribosome biogenesis and other pathophysiological processes |
| title_full | The role of USP36 in ribosome biogenesis and other pathophysiological processes |
| title_fullStr | The role of USP36 in ribosome biogenesis and other pathophysiological processes |
| title_full_unstemmed | The role of USP36 in ribosome biogenesis and other pathophysiological processes |
| title_short | The role of USP36 in ribosome biogenesis and other pathophysiological processes |
| title_sort | role of usp36 in ribosome biogenesis and other pathophysiological processes |
| topic | ubiquitin-specific peptidase 36 ribosome biosynthesis DNA replication stress hypoxia adaptation oxidative stress selective autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1650908/full |
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