Histone methyltransferase KMT2A promotes pulmonary fibrogenesis via targeting pro‐fibrotic factor PU.1 in fibroblasts

Histone methyltransferase KMT2A promotes pulmonary fibrogenesis via targeting pro‐fibrotic factor PU.1 in fibroblasts

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease driven by both environmental and genetic factors. Epigenetics refers to changes in gene expression or cellular phenotype that do not involve alterations to DNA sequence. KMT2A is a member of the SET family which catalyses...

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Main Authors: Wenting Lyu, Hui Wang, Tong Ji, Ling Liu, Haoran Chen, Li Fan, Guanning Zhong, Naihui Wan, Suwan Chen, Jingyu Chen, Hourong Cai, Hongyang Xu, Dongjin Wang, Jinghong Dai
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
epigenetics
fibroblast
histone methylation
idiopathic pulmonary fibrosis
Online Access:https://doi.org/10.1002/ctm2.70217
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