Resident Stem Cells and Renal Carcinoma
According to the cancer stem cell hypothesis tumors are maintained by a cancer stem cell population which is able to initiate and maintain tumors. Tumor-initiating stem cells display stem or progenitor cell properties such as self-renewal and capacity to re-establish tumors that recapitulate the tum...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/286985 |
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| _version_ | 1850168077533052928 |
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| author | Benedetta Bussolati Alessia Brossa Giovanni Camussi |
| author_facet | Benedetta Bussolati Alessia Brossa Giovanni Camussi |
| author_sort | Benedetta Bussolati |
| collection | DOAJ |
| description | According to the cancer stem cell hypothesis tumors are maintained by a cancer stem cell population which is able to initiate and maintain tumors. Tumor-initiating stem cells display stem or progenitor cell properties such as self-renewal and capacity to re-establish tumors that recapitulate the tumor of origin. In this paper, we discuss data relative to the presence of cancer stem cells in human renal carcinoma and their possible origin from normal resident stem cells. The cancer stem cells identified in human renal carcinomas are not derived from the normal CD133+ progenitors of the kidney, but rather from a more undifferentiated population that retains a mesenchymal phenotype. This population is able to self-renewal, clonogenicity, and in vivo tumor initiation. Moreover, they retain pluripotent differentiation capability, as they can generate not only the epithelial component of the tumor, but also tumor endothelial cells. This suggests that renal cancer stem cells may contribute to the intratumor vasculogenesis. |
| format | Article |
| id | doaj-art-e670e8e40687410bb28cc58bda96a680 |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-e670e8e40687410bb28cc58bda96a6802025-08-20T02:21:03ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/286985286985Resident Stem Cells and Renal CarcinomaBenedetta Bussolati0Alessia Brossa1Giovanni Camussi2Laboratory of Renal and Vascular Physiopathology, Department of Internal Medicine, Molecular Biotechnology Centre and Research Centre for Molecular Medicine, University of Turin, Cso Dogliotti 14, 10126 Turin, ItalyLaboratory of Renal and Vascular Physiopathology, Department of Internal Medicine, Molecular Biotechnology Centre and Research Centre for Molecular Medicine, University of Turin, Cso Dogliotti 14, 10126 Turin, ItalyLaboratory of Renal and Vascular Physiopathology, Department of Internal Medicine, Molecular Biotechnology Centre and Research Centre for Molecular Medicine, University of Turin, Cso Dogliotti 14, 10126 Turin, ItalyAccording to the cancer stem cell hypothesis tumors are maintained by a cancer stem cell population which is able to initiate and maintain tumors. Tumor-initiating stem cells display stem or progenitor cell properties such as self-renewal and capacity to re-establish tumors that recapitulate the tumor of origin. In this paper, we discuss data relative to the presence of cancer stem cells in human renal carcinoma and their possible origin from normal resident stem cells. The cancer stem cells identified in human renal carcinomas are not derived from the normal CD133+ progenitors of the kidney, but rather from a more undifferentiated population that retains a mesenchymal phenotype. This population is able to self-renewal, clonogenicity, and in vivo tumor initiation. Moreover, they retain pluripotent differentiation capability, as they can generate not only the epithelial component of the tumor, but also tumor endothelial cells. This suggests that renal cancer stem cells may contribute to the intratumor vasculogenesis.http://dx.doi.org/10.4061/2011/286985 |
| spellingShingle | Benedetta Bussolati Alessia Brossa Giovanni Camussi Resident Stem Cells and Renal Carcinoma International Journal of Nephrology |
| title | Resident Stem Cells and Renal Carcinoma |
| title_full | Resident Stem Cells and Renal Carcinoma |
| title_fullStr | Resident Stem Cells and Renal Carcinoma |
| title_full_unstemmed | Resident Stem Cells and Renal Carcinoma |
| title_short | Resident Stem Cells and Renal Carcinoma |
| title_sort | resident stem cells and renal carcinoma |
| url | http://dx.doi.org/10.4061/2011/286985 |
| work_keys_str_mv | AT benedettabussolati residentstemcellsandrenalcarcinoma AT alessiabrossa residentstemcellsandrenalcarcinoma AT giovannicamussi residentstemcellsandrenalcarcinoma |